Rabbit Anti-GNL3 Polyclonal Antibody – Cat# MBS847508

Nucleostemin (GNL3) Antibody – Rabbit Polyclonal

Name: GNL3 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS847508
Price: 430 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847508

May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Nucleostemin (GNL3), Polyclonal Antibody

Full Product Name

Anti-Nucleostemin Antibody

Product Gene Name

anti-GNL3 antibody

Product Synonym Names

E2IG3; NS; Guanine nucleotide-binding protein-like 3; E2-induced gene 3 protein; Novel nucleolar protein 47; NNP47; Nucleolar GTP-binding protein 3; Nucleostemin; Nucleostemin

Clonality

Polyclonal

Isotype

Rabbit IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Colorless liquid. In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH7.3; 30% glycerol and 0.01% sodium azide

Purity/Purification

Affinity purification. The antibody was purified by affinity chromatography

Concentration

1mg/ml (lot specific)

Specificity

Polyclonal antibody to detect endogenous levels of Nucleostemin in human samples

Preparation and Storage

Store at -20 degree C
The antibody solution should be gently mixed before use.
Shelf life: ~12 months

OMIM

608011

3D Structure

ModBase 3D Structure for Q9BVP2

Immunogen

Recombinant full length protein of human Nucleostemin

Positive Control

WB: HEK293T cell lysates, IF: A549 cells

Product Categories/Family for anti-GNL3 antibody

Stem Cells; Neuroscience Antibodies

Applications Tested/Suitable for anti-GNL3 antibody

Western Blot (WB), Immunofluorescence (IF)

Application Notes for anti-GNL3 antibody

WB: 1:500-1:1000
IF: 1:10-1:100
ICC: 1:10-1:100

Other Notes

Small volumes of anti-GNL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GNL3 purchase

MBS847508 is an antibody targeting GNL3. Also known as Anti-Nucleostemin Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GNL3. It may not necessarily be applicable to this product.

NCBI GeneID

26354

UniProt Primary Accession #

Q9BVP2

UniProt Protein Name

Guanine nucleotide-binding protein-like 3

UniProt Synonym Protein Names

E2-induced gene 3 protein; Novel nucleolar protein 47; NNP47; Nucleolar GTP-binding protein 3; Nucleostemin

Protein Family

Guanine nucleotide-binding protein

UniProt Gene Name

GNL3

UniProt Synonym Gene Names

E2IG3; NS

UniProt Entry Name

GNL3_HUMAN

UniProt Comments for GNL3

GNL3: May be required to maintain the proliferative capacity of stem cells and may play an important role in tumorigenesis. May interact with p53/TP53 via its basic domain. Increased levels in lung tissue in cancer patients. Belongs to the MMR1/HSR1 GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Cell cycle regulation; Nucleolus; RNA-binding

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: nucleoplasm; extracellular space; membrane; nucleolus; nucleus

Molecular Function: GTPase activity; protein binding; GTP binding

Biological Process: cell proliferation; metabolic process; ribosome biogenesis and assembly; regulation of cell proliferation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.