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PLAGL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847511

Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Product Overview

Product Name
PLAGL1, Polyclonal Antibody
Full Product Name
Anti-PLAGL1 Antibody
Product Gene Name
Product Synonym Names
LOT1; ZAC; Zinc finger protein PLAGL1; Lost on transformation 1; LOT-1; Pleiomorphic adenoma-like protein 1; Tumor suppressor ZAC
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
Colorless liquid. In phosphate buffered saline, pH7.4, 150mM, NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity purification
Concentration
1mg/ml (lot specific)
Specificity
Polyclonal antibody to detect endogenous levels of PLAGL1 in human and rat samples
Preparation and Storage
Store at -20 degree C
The antibody solution should be gently mixed before use.
Shelf life: ~12 months
Molecular Weight
50,819 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (144261437..144385735, complement). Location: 6q24-q25
OMIM
603044
3D Structure
ModBase 3D Structure for Q9UM63
Immunogen
A synthesized peptide
Positive Control
WB: 293 cells, rat muscle extracts; IF: 293 cells
Applications Tested/Suitable for anti-PLAGL1 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-PLAGL1 antibody
WB: 1:500-1:1000
IF: 1:100-1:500
ICC: 1:100-1:500
ELISA (peptide): 1:20,000-1:40,000

Testing Data of anti-PLAGL1 antibody

Rabbit Anti-PLAGL1 Polyclonal Antibody – Cat# MBS847511

Other Notes

Small volumes of anti-PLAGL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLAGL1 purchase

MBS847511 is an antibody targeting PLAGL1. Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PLAGL1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
zinc finger protein PLAGL1 isoform 2
NCBI Official Synonym Full Names
pleiomorphic adenoma gene-like 1
NCBI Official Symbol
PLAGL1
NCBI Official Synonym Symbols
ZAC; LOT1; ZAC1
UniProt Protein Name
Zinc finger protein PLAGL1
UniProt Synonym Protein Names
Lost on transformation 1; LOT-1; Pleiomorphic adenoma-like protein 1; Tumor suppressor ZAC
Protein Family
UniProt Gene Name
PLAGL1
UniProt Synonym Gene Names
LOT1; ZAC; LOT-1
UniProt Entry Name
PLAL1_HUMAN
NCBI Protein Information
zinc finger protein PLAGL1; LOT-1; PLAG-like 1; tumor supressor ZAC; tumor suppressor ZAC; lost on transformation 1; pleiomorphic adenoma-like protein 1

NCBI Summary for PLAGL1

This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5' UTR and encoding two different isoforms, have been found for this gene. [provided by RefSeq, Oct 2010]
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UniProt Comments for PLAGL1

PLAGL1: Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 6q24-q25

Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; nucleus

Molecular Function: DNA binding; metal ion binding

Biological Process: transcription from RNA polymerase II promoter; apoptosis; positive regulation of transcription from RNA polymerase II promoter; cell differentiation; cell cycle arrest

Disease: Diabetes Mellitus, Transient Neonatal, 1
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PLAGL1 antibody

 Reference Product  PubMed Publications
 TP53 antibody  >2 publications with PLAGL1 and TP53
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