• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Cripto 1 (CRIPTO1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847525

GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. Could play a… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
Cripto 1 (Cripto1), Polyclonal Antibody
Full Product Name
Anti-Cripto 1 Antibody
Product Gene Name
anti-Cripto1 antibody
Product Synonym Names
CRIPTO; Teratocarcinoma-derived growth factor 1; Cripto-1 growth factor; CRGF; Epidermal growth factor-like cripto protein CR1
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Colorless liquid. In phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Purity/Purification
Affinity purification
Concentration
1mg/ml (lot specific)
Specificity
Polyclonal antibody to detect endogenous levels of Cripto 1 in human, mouse and rat samples
Preparation and Storage
Store at -20 degree C
The antibody solution should be gently mixed before use.
Shelf life: ~12 months
Molecular Weight
21,169 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (46616045..46623953). Location: 3p21.31
OMIM
187395
3D Structure
ModBase 3D Structure for P13385
Immunogen
A synthesized peptide derived from human Cripto 1
Positive Control
WB: NCCIT lysate, IHC: Human lung tissue

Product Categories/Family for anti-Cripto1 antibody

Stem Cells; Antibodies & Supporting Tools; IHC Tested Antibodies
Applications Tested/Suitable for anti-Cripto1 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-Cripto1 antibody
WB: 1:500-1:200
IHC: 1:50-1:200
ELISA (peptide): 1:20,000-1:40,000

Western Blot (WB) of anti-Cripto1 antibody

Rabbit Anti-CRIPTO1 Polyclonal Antibody – Cat# MBS847525

Other Notes

Small volumes of anti-Cripto1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cripto1 purchase

MBS847525 is an antibody targeting Cripto1. Also known as Anti-Cripto 1 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Cripto1. It may not necessarily be applicable to this product.

NCBI GI #
292494883
NCBI GeneID
6997
NCBI Accession #
NP_001167607.1
UniProt Primary Accession #
P13385
UniProt Secondary Accession #
Q8TCC1
UniProt Related Accession #
P13385
GenBank Nucleotide #
NM_001174136.1
NCBI Official Full Name
teratocarcinoma-derived growth factor 1 isoform 2
NCBI Official Synonym Full Names
teratocarcinoma-derived growth factor 1
NCBI Official Symbol
TDGF1
NCBI Official Synonym Symbols
CR; CRGF; CRIPTO
UniProt Protein Name
Teratocarcinoma-derived growth factor 1
UniProt Synonym Protein Names
Cripto-1 growth factor; CRGF; Epidermal growth factor-like cripto protein CR1
Protein Family
Teratocarcinoma-derived growth factor
UniProt Gene Name
TDGF1
UniProt Synonym Gene Names
CRIPTO; CRGF
UniProt Entry Name
TDGF1_HUMAN
NCBI Protein Information
teratocarcinoma-derived growth factor 1; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1

NCBI Summary for Cripto1

This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Show more

UniProt Comments for Cripto1

TDGF1: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Interacts with the activin type-1 receptor ACVR1B. Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; Cell cycle regulation; Membrane protein, peripheral; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: extrinsic to plasma membrane; Golgi apparatus; extracellular space; cell surface; perinuclear region of cytoplasm; apical plasma membrane; plasma membrane; nucleus; lipid raft

Molecular Function: protein binding; growth factor activity; receptor binding

Biological Process: activation of MAPK activity; somatic stem cell maintenance; heart development; regulation of signal transduction; gastrulation; Wnt receptor signaling pathway through beta-catenin; cardiac muscle cell differentiation; BMP signaling pathway; positive regulation of fibroblast proliferation; mammary gland development; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; cell differentiation; vasculogenesis; positive regulation of cell-matrix adhesion; epidermal growth factor receptor signaling pathway; in utero embryonic development; morphogenesis of a branching structure; positive regulation of peptidyl-tyrosine phosphorylation; embryonic development; peptidyl-serine phosphorylation; cell migration during sprouting angiogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of cell migration; negative regulation of apoptosis
Show more

Research Articles on Cripto1

1. Cross-talk between Cripto-1 and the Wnt/beta-catenin signaling pathway might play a role in mammary transformation leading to a more aggressive behavior of mammary cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Cripto1 antibody

 Reference Product  PubMed Publications
 NODAL antibody  >80 publications with Cripto1 and NODAL
 ACVR1B antibody  >18 publications with Cripto1 and ACVR1B
 ACVR2A antibody  >3 publications with Cripto1 and ACVR2A
 ACVR1C antibody  >3 publications with Cripto1 and ACVR1C
 ACVR2B antibody  >1 publications with Cripto1 and ACVR2B

Pathways associated with anti-Cripto1 antibody

 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Glypican 1 Network Pathway antibodies  Glypican 1 Network Pathway Diagram
 Regulation Of Signaling By NODAL Pathway antibodies  Regulation Of Signaling By NODAL Pathway Diagram
 Signaling By NODAL Pathway antibodies  Signaling By NODAL Pathway Diagram

Diseases associated with anti-Cripto1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >120 publications with Cripto1 and Neoplasms
 Skin Diseases Antibodies  >31 publications with Cripto1 and Skin Diseases
 Gastrointestinal Diseases Antibodies  >29 publications with Cripto1 and Gastrointestinal Diseases
 Intestinal Neoplasms Antibodies  >25 publications with Cripto1 and Intestinal Neoplasms
 Adenocarcinoma Antibodies  >19 publications with Cripto1 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >12 publications with Cripto1 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >11 publications with Cripto1 and Nervous System Diseases
 Holoprosencephaly Antibodies  >9 publications with Cripto1 and Holoprosencephaly
 Craniofacial Abnormalities Antibodies  >7 publications with Cripto1 and Craniofacial Abnormalities
 Nervous System Malformations Antibodies  >7 publications with Cripto1 and Nervous System Malformations

Organs/Tissues associated with anti-Cripto1 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >57 publications with Cripto1 and Embryonic Tissue
 Muscle Antibodies  >22 publications with Cripto1 and Muscle
 Brain Antibodies  >12 publications with Cripto1 and Brain
 Liver Antibodies  >11 publications with Cripto1 and Liver
 Testis Antibodies  >7 publications with Cripto1 and Testis
 Uterus Antibodies  >6 publications with Cripto1 and Uterus
 Kidney Antibodies  >4 publications with Cripto1 and Kidney
 Prostate Antibodies  >4 publications with Cripto1 and Prostate
 Intestine Antibodies  >4 publications with Cripto1 and Intestine
 Spleen Antibodies  >3 publications with Cripto1 and Spleen
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000