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FOXD3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847531

Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural… More details

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Testing Data View PDF
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Product Overview

Product Name
FOXD3, Polyclonal Antibody
Full Product Name
Anti-FOXD3 Antibody
Product Gene Name
anti-FOXD3 antibody
Product Synonym Names
AIS1; forkhead box D3; Forkhead box protein D3; foxd3; FOXD3_HUMAN; Genesis; HFH2; HNF3/FH transcription factor genesis; VAMAS2
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Colorless liquid. In phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Purity/Purification
Affinity purification
Concentration
1mg/ml (lot specific)
Specificity
Polyclonal antibody to detect endogenous levels of FOXD3 in human, mouse and rat sample
Preparation and Storage
Store at -20 degree C
The antibody solution should be gently mixed before use.
Shelf life: ~12 months
Molecular Weight
47,630 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (63788730..63790797). Location: 1p31.3
OMIM
607836
3D Structure
ModBase 3D Structure for Q9UJU5
Immunogen
A synthesized peptide
Positive Control
WB: HUVEC cells, IF/ICC: HUVEC cells, IHC: Human brain tissue

Product Categories/Family for anti-FOXD3 antibody

Stem Cells; Antibodies & Supporting Tools; IHC Tested Antibodies
Applications Tested/Suitable for anti-FOXD3 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-FOXD3 antibody
WB: 1:500-1:1000
IHC: 1:50-1:200
IF: 1:100-1:500
ICC: 1:100-1:500
ELISA (peptide): 1:20,000-1:40,000

Testing Data of anti-FOXD3 antibody

Rabbit Anti-FOXD3 Polyclonal Antibody – Cat# MBS847531

Other Notes

Small volumes of anti-FOXD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FOXD3 purchase

MBS847531 is an antibody targeting FOXD3. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FOXD3. It may not necessarily be applicable to this product.

NCBI GI #
6912372
NCBI GeneID
27022
NCBI Accession #
NP_036315.1
UniProt Primary Accession #
Q9UJU5
UniProt Secondary Accession #
Q9BYM2; Q9UDD1
UniProt Related Accession #
Q9UJU5
GenBank Nucleotide #
NM_012183.2
NCBI Official Full Name
forkhead box protein D3
NCBI Official Synonym Full Names
forkhead box D3
NCBI Official Symbol
FOXD3
NCBI Official Synonym Symbols
AIS1; HFH2; VAMAS2; Genesis
UniProt Protein Name
Forkhead box protein D3
UniProt Synonym Protein Names
HNF3/FH transcription factor genesis
Protein Family
Forkhead box protein
UniProt Gene Name
FOXD3
UniProt Synonym Gene Names
HFH2
UniProt Entry Name
FOXD3_HUMAN
NCBI Protein Information
forkhead box protein D3; HNF3/FH transcription factor genesis

NCBI Summary for FOXD3

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008]

UniProt Comments for FOXD3

FOXD3: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: nucleoplasm; nuclear chromatin

Molecular Function: protein binding; double-stranded DNA binding; transcription factor activity

Biological Process: embryonic placenta development; transcription, DNA-dependent; in utero embryonic development; somatic stem cell maintenance; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; trophectodermal cell differentiation

Disease: Autoimmune Disease, Susceptibility To, 1
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Research Articles on FOXD3

1. Methylation profile analyses identified the promoter of FOXD3 as the only genomic region with increased methylation in mice and humans during progression of Helicobacter pylori-associated gastric tumors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FOXD3 antibody

 Reference Product  PubMed Publications
 POU5F1 antibody  >16 publications with FOXD3 and POU5F1

Pathways associated with anti-FOXD3 antibody

 Products by Pathway  Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Wnt Signaling Pathway And Pluripotency antibodies  Wnt Signaling Pathway And Pluripotency Diagram

Diseases associated with anti-FOXD3 antibody

 Disease Name  Pubmed Publications
 Drug Toxicity Antibodies  >2 publications with FOXD3 and Drug Toxicity
 Abnormalities, Multiple Antibodies  >2 publications with FOXD3 and Abnormalities, Multiple
 Sarcoma Antibodies  >2 publications with FOXD3 and Sarcoma
 Ovarian Neoplasms Antibodies  >1 publications with FOXD3 and Ovarian Neoplasms
 Heart Defects, Congenital Antibodies  >1 publications with FOXD3 and Heart Defects, Congenital
 Necrosis Antibodies  >1 publications with FOXD3 and Necrosis
 Respiratory Tract Diseases Antibodies  >1 publications with FOXD3 and Respiratory Tract Diseases
 Abnormalities, Drug-Induced Antibodies  >1 publications with FOXD3 and Abnormalities, Drug-Induced
 AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 1 Antibodies  >1 publications with FOXD3 and AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 1

Organs/Tissues associated with anti-FOXD3 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >41 publications with FOXD3 and Embryonic Tissue
 Eye Antibodies  >7 publications with FOXD3 and Eye
 Intestine Antibodies  >3 publications with FOXD3 and Intestine
 Heart Antibodies  >3 publications with FOXD3 and Heart
 Ear Antibodies  >2 publications with FOXD3 and Ear
 Kidney Antibodies  >2 publications with FOXD3 and Kidney
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