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SHB Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847547

Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen… More details

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Product Overview

Product Name
SHB, Polyclonal Antibody
Full Product Name
Anti-SHB Antibody
Product Gene Name
anti-SHB antibody
Product Synonym Names
SH2 domain containing adapter protein B; SH2 domain-containing adapter protein B; SHB (Src homology 2 domain containing) adaptor protein B; SHB adaptor protein (a Src homology 2 protein); SHB adaptor protein; Shb; SHB_HUMAN; Src homology 2 domain containing adaptor protein B; Src homology 2 protein
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Mouse, Human
Form/Format
Colorless liquid. In phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity purification
Concentration
1mg/ml (lot specific)
Specificity
Polyclonal antibody to detect endogenous levels of SHB in human and mouse samples
Preparation and Storage
Store at -20 degree C
The antibody solution should be gently mixed before use.
Shelf life: ~12 months
Molecular Weight
55,042 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (37915895..38069210, complement). Location: 9p13.2
OMIM
600314
3D Structure
ModBase 3D Structure for Q15464
Immunogen
A synthesized peptide

Product Categories/Family for anti-SHB antibody

GM-CSF; Stem Cell Research Tools; Embryonic Stem Cells; Antibodies; Antibodies & Supporting Tools; Primary Antibodies (A-Z); IHC Tested Antibodies
Applications Tested/Suitable for anti-SHB antibody
Immunocytochemistry (ICC), Western Blot (WB), ELISA (EIA)
Application Notes for anti-SHB antibody
IF: 1:100-1:500
ICC: 1:100-1:500
WB: 1:500~1:1000
ELISA (peptide): 1:20,000-1:40,000

Immunocytochemistry/Immunofluorescence (ICC/IF)) of anti-SHB antibody

Rabbit Anti-SHB Polyclonal Antibody – Cat# MBS847547

Western Blot (WB) of anti-SHB antibody

Rabbit Anti-SHB Polyclonal Antibody, Western Blot (WB) – Cat# MBS847547

Other Notes

Small volumes of anti-SHB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SHB purchase

MBS847547 is an antibody targeting SHB. Reactive in Mouse, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SHB. It may not necessarily be applicable to this product.

NCBI GI #
106879210
NCBI GeneID
6461
NCBI Accession #
NP_003019.2
UniProt Primary Accession #
Q15464
UniProt Secondary Accession #
Q504U5; Q5VUM8; B9EGM0; D3DRQ5
UniProt Related Accession #
Q15464
GenBank Nucleotide #
NM_003028.2
NCBI Official Full Name
SH2 domain-containing adapter protein B
NCBI Official Synonym Full Names
Src homology 2 domain containing adaptor protein B
NCBI Official Symbol
SHB
NCBI Official Synonym Symbols
bA3J10.2; RP11-3J10.8
UniProt Protein Name
SH2 domain-containing adapter protein B
Protein Family
SH2 domain-containing adapter protein
UniProt Gene Name
SHB
UniProt Entry Name
SHB_HUMAN
NCBI Protein Information
SH2 domain-containing adapter protein B; SHB adaptor protein (a Src homology 2 protein); SHB (Src homology 2 domain containing) adaptor protein B

UniProt Comments for SHB

SHB: Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9p13.2

Cellular Component: plasma membrane; cytosol

Molecular Function: protein binding; SH3/SH2 adaptor activity

Biological Process: positive regulation of signal transduction; apoptosis; angiogenesis; signal transduction; cell differentiation; vascular endothelial growth factor receptor signaling pathway
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Research Articles on SHB

1. It is concluded that SHB and angiogenic factors promote the development of cells expressing PDX-1 and insulin in EBs and that such cells can be separated by FACS.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SHB antibody

 Reference Product  PubMed Publications
 SRC antibody  >40 publications with SHB and SRC
 PDGFRB antibody  >6 publications with SHB and PDGFRB
 PDGFRA antibody  >4 publications with SHB and PDGFRA
 GRB2 antibody  >3 publications with SHB and GRB2
 CRK antibody  >3 publications with SHB and CRK
 FGFR1 antibody  >3 publications with SHB and FGFR1
 LAT antibody  >3 publications with SHB and LAT
 GRAP2 antibody  >2 publications with SHB and GRAP2
 EPS8 antibody  >2 publications with SHB and EPS8
 KDR antibody  >1 publications with SHB and KDR

Pathways associated with anti-SHB antibody

 Products by Pathway  Pathway Diagram
 PDGFR-alpha Signaling Pathway antibodies  PDGFR-alpha Signaling Pathway Diagram
 PDGFR-beta Signaling Pathway antibodies  PDGFR-beta Signaling Pathway Diagram
 Signaling Events Mediated By VEGFR1 And VEGFR2 Pathway antibodies  Signaling Events Mediated By VEGFR1 And VEGFR2 Pathway Diagram

Diseases associated with anti-SHB antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >25 publications with SHB and Neoplasms
 Death Antibodies  >15 publications with SHB and Death
 Cardiovascular Diseases Antibodies  >14 publications with SHB and Cardiovascular Diseases
 Liver Diseases Antibodies  >10 publications with SHB and Liver Diseases
 Immune System Diseases Antibodies  >8 publications with SHB and Immune System Diseases
 Inflammation Antibodies  >7 publications with SHB and Inflammation
 Drug Toxicity Antibodies  >4 publications with SHB and Drug Toxicity
 Nervous System Diseases Antibodies  >4 publications with SHB and Nervous System Diseases
 Kidney Diseases Antibodies  >3 publications with SHB and Kidney Diseases
 Cell Transformation, Neoplastic Antibodies  >3 publications with SHB and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-SHB antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >27 publications with SHB and Vascular
 Skin Antibodies  >16 publications with SHB and Skin
 Liver Antibodies  >14 publications with SHB and Liver
 Muscle Antibodies  >13 publications with SHB and Muscle
 Brain Antibodies  >12 publications with SHB and Brain
 Lung Antibodies  >10 publications with SHB and Lung
 Pancreas Antibodies  >10 publications with SHB and Pancreas
 Kidney Antibodies  >9 publications with SHB and Kidney
 Heart Antibodies  >9 publications with SHB and Heart
 Embryonic Tissue Antibodies  >5 publications with SHB and Embryonic Tissue
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