Phospho-MAPKAPK5 (MAPKAPK5) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]

MAPKAPK5: a member of the MAPKAPK family of protein kinases. Activated through phosphorylation by MAP kinases including ERK, p38-alpha, and MAPp38-beta In response to cellular stress and proinflammatory cytokines. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.

Protein type: Protein kinase, CAMK; EC 2.7.11.1; Tumor suppressor; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CAMK group; MAPKAPK family; MAPKAPK subfamily

Chromosomal Location of Human Ortholog: 12q24.13

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; p53 binding; mitogen-activated protein kinase binding; ATP binding

Biological Process: regulation of translation; negative regulation of TOR signaling pathway; activation of MAPK activity; protein amino acid autophosphorylation; Ras protein signal transduction; MAPKKK cascade; signal transduction