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Caspase-7 (CASP7) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847605

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at… More details

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Product Overview

Product Name
Caspase-7 (CASP7), Polyclonal Antibody
Full Product Name
Anti-Caspase-7 Antibody
Product Gene Name
anti-CASP7 antibody
Product Synonym Names
Apoptotic protease Mch-3; CMH-1; ICE-LAP3; ICE-like apoptotic protease 3; LICE2; MCH3; Caspase-7
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Mouse, Human
Form/Format
Colorless liquid. PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Purity/Purification
Affinity purification
Concentration
0.1mg/ml (lot specific)
Specificity
Polyclonal antibody to detect Caspase-7 in human and mouse samples.
Preparation and Storage
Store at -20 degree C
The antibody solution should be gently mixed before use.
Shelf life: ~12 months
Molecular Weight
34,277 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (115438921..115490668). Location: 10q25
OMIM
601761
3D Structure
ModBase 3D Structure for P55210
Immunogen
Recombinant protein of human CASP7

Product Categories/Family for anti-CASP7 antibody

Cancer; Antibodies & Supporting Tools; Primary Antibodies (A-Z); Diabetes; Obesity & Metabolic Syndrome; Lipids Metabolism; Antibodies; IHC Tested Antibodies; Drug Metabolism; Disposition; Antibodies
Applications Tested/Suitable for anti-CASP7 antibody
Immunohistochemistry (IHC), Western Blot (WB), ELISA (EIA)
Application Notes for anti-CASP7 antibody
WB: 1:200-1:1000
IHC: 1:25-1:100

Immunohistochemistry (IHC) of anti-CASP7 antibody

Rabbit Anti-CASP7 Polyclonal Antibody – Cat# MBS847605

Immunohistochemistry (IHC) of anti-CASP7 antibody

Rabbit Anti-CASP7 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS847605

Western Blot (WB) of anti-CASP7 antibody

Rabbit Anti-CASP7 Polyclonal Antibody, Western Blot (WB) – Cat# MBS847605

Other Notes

Small volumes of anti-CASP7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CASP7 purchase

MBS847605 is an antibody targeting CASP7. Also known as Anti-Caspase-7 Antibody. Reactive in Mouse, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CASP7. It may not necessarily be applicable to this product.

NCBI GI #
4502581
NCBI GeneID
840
NCBI Accession #
NP_001218.1
UniProt Primary Accession #
P55210
UniProt Secondary Accession #
Q13364; Q53YD5; Q5SVL0; Q5SVL3; Q96BA0; B4DQU7; B5BU45; D3DRB8
UniProt Related Accession #
P55210
GenBank Nucleotide #
NM_001227.4
NCBI Official Full Name
caspase-7 isoform alpha
NCBI Official Synonym Full Names
caspase 7, apoptosis-related cysteine peptidase
NCBI Official Symbol
CASP7
NCBI Official Synonym Symbols
MCH3; CMH-1; LICE2; CASP-7; ICE-LAP3
UniProt Protein Name
Caspase-7
UniProt Synonym Protein Names
Apoptotic protease Mch-3; CMH-1; ICE-like apoptotic protease 3
Protein Family
Caspase
UniProt Gene Name
CASP7
UniProt Synonym Gene Names
MCH3; CASP-7; ICE-LAP3
UniProt Entry Name
CASP7_HUMAN
NCBI Protein Information
caspase-7; apoptotic protease MCH-3; ICE-like apoptotic protease 3; caspase 7, apoptosis-related cysteine protease

UniProt Comments for CASP7

CASP7: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain. Inhibited by isatin sulfonamides. Belongs to the peptidase C14A family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.22.60; Endoplasmic reticulum; Protease; Mitochondrial; Apoptosis

Chromosomal Location of Human Ortholog: 10q25

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity

Biological Process: apoptosis; caspase activation via cytochrome c; proteolysis; cell structure disassembly during apoptosis
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Research Articles on CASP7

1. Genetic variations of CASP7 may modulate overall survival and progress-free survival of patients with advanced non-small cell lung cancer treated with platinum-based chemotherapy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CASP7 antibody

 Reference Product  PubMed Publications
 XIAP antibody  >71 publications with CASP7 and XIAP
 BIRC5 antibody  >41 publications with CASP7 and BIRC5
 PARP1 antibody  >31 publications with CASP7 and PARP1
 CASP10 antibody  >24 publications with CASP7 and CASP10
 GZMB antibody  >13 publications with CASP7 and GZMB
 MAX antibody  >12 publications with CASP7 and MAX
 CASP2 antibody  >7 publications with CASP7 and CASP2
 BIRC2 antibody  >5 publications with CASP7 and BIRC2
 HTT antibody  >5 publications with CASP7 and HTT
 BIRC3 antibody  >4 publications with CASP7 and BIRC3

Pathways associated with anti-CASP7 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway antibodies  Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Apoptosis Modulation By HSP70 Pathway antibodies  Apoptosis Modulation By HSP70 Pathway Diagram

Diseases associated with anti-CASP7 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >612 publications with CASP7 and Neoplasms
 Necrosis Antibodies  >224 publications with CASP7 and Necrosis
 Drug Toxicity Antibodies  >165 publications with CASP7 and Drug Toxicity
 Breast Neoplasms Antibodies  >138 publications with CASP7 and Breast Neoplasms
 Inflammation Antibodies  >77 publications with CASP7 and Inflammation
 Nervous System Diseases Antibodies  >67 publications with CASP7 and Nervous System Diseases
 Prostatic Neoplasms Antibodies  >62 publications with CASP7 and Prostatic Neoplasms
 Cardiovascular Diseases Antibodies  >50 publications with CASP7 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >50 publications with CASP7 and Neoplasms, Experimental
 Liver Diseases Antibodies  >50 publications with CASP7 and Liver Diseases

Organs/Tissues associated with anti-CASP7 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >153 publications with CASP7 and Blood
 Brain Antibodies  >96 publications with CASP7 and Brain
 Liver Antibodies  >92 publications with CASP7 and Liver
 Lung Antibodies  >91 publications with CASP7 and Lung
 Prostate Antibodies  >66 publications with CASP7 and Prostate
 Kidney Antibodies  >58 publications with CASP7 and Kidney
 Vascular Antibodies  >56 publications with CASP7 and Vascular
 Nerve Antibodies  >54 publications with CASP7 and Nerve
 Muscle Antibodies  >53 publications with CASP7 and Muscle
 Heart Antibodies  >43 publications with CASP7 and Heart
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