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IL10RA Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847623

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory… More details

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Product Overview

Product Name
IL10RA, Polyclonal Antibody
Full Product Name
Anti-IL10RA Antibody
Product Gene Name
anti-IL10RA antibody
Product Synonym Names
CD210; CDw210a; HIL-10R; Interleukin 10 receptor alpha; Interleukin-10 receptor subunit 1; Interleukin-10 receptor subunit alpha
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Colorless liquid. PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Purity/Purification
Affinity purification
Concentration
0.6mg/ml (lot specific)
Specificity
Polyclonal antibody to detect IL10RA in Human samples.
Preparation and Storage
Store at -20 degree C
The antibody solution should be gently mixed before use.
Shelf life: ~12 months
Molecular Weight
63,003 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (117857106..117872198). Location: 11q23
OMIM
146933
3D Structure
ModBase 3D Structure for Q13651
Immunogen
Recombinant protein of human IL10RA

Product Categories/Family for anti-IL10RA antibody

Immunology; Cancer Research; Antibodies & Supporting Tools; Primary Antibodies (A-Z); IHC Tested Antibodies
Applications Tested/Suitable for anti-IL10RA antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-IL10RA antibody
IHC 1:25-1:100

Immunohistochemistry (IHC) of anti-IL10RA antibody

Rabbit Anti-IL10RA Polyclonal Antibody – Cat# MBS847623

Immunohistochemistry (IHC) of anti-IL10RA antibody

Rabbit Anti-IL10RA Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS847623

Other Notes

Small volumes of anti-IL10RA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL10RA purchase

MBS847623 is an antibody targeting IL10RA. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL10RA. It may not necessarily be applicable to this product.

NCBI GI #
222136575
NCBI GeneID
3587
NCBI Accession #
NP_001549.2
UniProt Primary Accession #
Q13651
UniProt Secondary Accession #
A8K6I0; B0YJ27
UniProt Related Accession #
Q13651
GenBank Nucleotide #
NM_001558.3
NCBI Official Full Name
interleukin-10 receptor subunit alpha
NCBI Official Synonym Full Names
interleukin 10 receptor, alpha
NCBI Official Symbol
IL10RA
NCBI Official Synonym Symbols
CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1
UniProt Protein Name
Interleukin-10 receptor subunit alpha
UniProt Synonym Protein Names
CDw210a; Interleukin-10 receptor subunit 1
Protein Family
Interleukin-10 receptor
UniProt Gene Name
IL10RA
UniProt Synonym Gene Names
IL10R; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; IL-10R subunit 1; IL-10R1
UniProt Entry Name
I10R1_HUMAN
NCBI Protein Information
interleukin-10 receptor subunit alpha; IL-10RA; IL-10R subunit 1; IL-10R subunit alpha; IL-10 receptor subunit alpha; interleukin-10 receptor subunit 1; interleukin-10 receptor alpha chain

UniProt Comments for IL10RA

IL10RA: a receptor for interleukin 10 structurally related to interferon receptors. Mediates the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: plasma membrane; integral to membrane

Molecular Function: signal transducer activity; protein binding; interleukin-10 binding; interleukin-10 receptor activity; receptor activity

Biological Process: cytokine and chemokine mediated signaling pathway; response to lipopolysaccharide

Disease: Inflammatory Bowel Disease 28, Autosomal Recessive
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Research Articles on IL10RA

1. The dynamic genome-wide transcriptional responses were nearly identical at early time points following stimulation (when STAT3 is active in response to both IL-6 and IL-10) but divergent at later times (when STAT3 is active only in response to IL-10).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL10RA antibody

 Reference Product  PubMed Publications
 IL10 antibody  >19 publications with IL10RA and IL10
 IL10RB antibody  >10 publications with IL10RA and IL10RB
 JAK1 antibody  >1 publications with IL10RA and JAK1

Pathways associated with anti-IL10RA antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Toxoplasmosis Pathway antibodies  Toxoplasmosis Pathway Diagram
 Toxoplasmosis Pathway antibodies  Toxoplasmosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram

Diseases associated with anti-IL10RA antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >10 publications with IL10RA and Inflammation
 Cardiovascular Diseases Antibodies  >4 publications with IL10RA and Cardiovascular Diseases
 Neoplasms Antibodies  >4 publications with IL10RA and Neoplasms
 Necrosis Antibodies  >4 publications with IL10RA and Necrosis
 Brain Diseases Antibodies  >2 publications with IL10RA and Brain Diseases
 Liver Diseases Antibodies  >2 publications with IL10RA and Liver Diseases
 Skin Diseases Antibodies  >2 publications with IL10RA and Skin Diseases
 Disease Models, Animal Antibodies  >1 publications with IL10RA and Disease Models, Animal
 Lung Diseases Antibodies  >1 publications with IL10RA and Lung Diseases
 Kidney Diseases Antibodies  >1 publications with IL10RA and Kidney Diseases

Organs/Tissues associated with anti-IL10RA antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >15 publications with IL10RA and Blood
 Brain Antibodies  >3 publications with IL10RA and Brain
 Bone Antibodies  >3 publications with IL10RA and Bone
 Skin Antibodies  >2 publications with IL10RA and Skin
 Vascular Antibodies  >2 publications with IL10RA and Vascular
 Tonsil Antibodies  >1 publications with IL10RA and Tonsil
 Pharynx Antibodies  >1 publications with IL10RA and Pharynx
 Lung Antibodies  >1 publications with IL10RA and Lung
 Spleen Antibodies  >1 publications with IL10RA and Spleen
 Thymus Antibodies  >1 publications with IL10RA and Thymus
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