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CD274 Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847677

MBS847677 is an antibody targeting Cd274. Also known as Anti-PD-L1 (CD274) (B7-H1), Rabbit Monoclonal Antibody. Reactive in Human. Host: Rabbit. Rabbit monoclonal to PD-L1 (CD274) (B7-H1) . More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PD-L1 (Cd274), Monoclonal Antibody
Full Product Name
Anti-PD-L1 (CD274) (B7-H1), Rabbit Monoclonal Antibody
Product Gene Name
anti-Cd274 antibody
Product Synonym Names
Programmed cell death 1 ligand 1
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
RM320
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purity/Purification
Protein A affinity purified from an animal origin-free culture supernatant.
Specificity
Affinity purified rabbit monoclonal to PD-L1 (CD274)(B7-H1). Clone RM320 reacts to human PD-L1 (CD274) (B7-H1)
Preparation and Storage
Store at -20 degree C
The antibody solution should be gently mixed before use.
Shelf life: ~12 months
3D Structure
ModBase 3D Structure for Q9EP73
Immunogen
A peptide corresponding to the C-terminus of human PD-L1

Product Categories/Family for anti-Cd274 antibody

Antibodies & Supporting Tools; Rabbit Monoclonal Antibodies; Primary Antibodies (A-Z)
Applications Tested/Suitable for anti-Cd274 antibody
Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western Blot (WB)
Application Notes for anti-Cd274 antibody
IHC: 1:200-1:1000 dilution
WB: 1:500-1:1000 dilution
ICC: 1:200-1:500 dilution

Immunohistochemistry (IHC) of anti-Cd274 antibody

Rabbit Anti-CD274 Monoclonal Antibody – Cat# MBS847677

Immunohistochemistry (IHC) of anti-Cd274 antibody

Rabbit Anti-CD274 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS847677

Western Blot (WB) of anti-Cd274 antibody

Rabbit Anti-CD274 Monoclonal Antibody, Western Blot (WB) – Cat# MBS847677

Other Notes

Small volumes of anti-Cd274 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Cd274. It may not necessarily be applicable to this product.

NCBI GI #
11230798
NCBI GeneID
60533
NCBI Accession #
NP_068693.1
UniProt Primary Accession #
Q9EP73
UniProt Related Accession #
Q9EP73
GenBank Nucleotide #
NM_021893.3
NCBI Official Full Name
programmed cell death 1 ligand 1
NCBI Official Synonym Full Names
CD274 antigen
NCBI Official Symbol
Cd274
NCBI Official Synonym Symbols
B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik
UniProt Protein Name
Programmed cell death 1 ligand 1
UniProt Synonym Protein Names
B7 homolog 1; B7-H1; CD_antigen: CD274
Protein Family
Programmed cell death
UniProt Gene Name
Cd274
UniProt Synonym Gene Names
B7h1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7-H1
UniProt Entry Name
PD1L1_MOUSE
NCBI Protein Information
programmed cell death 1 ligand 1; B7 homolog 1; PDCD1 ligand 1; programmed death ligand 1

UniProt Comments for Cd274

CD274: Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: protein binding

Biological Process: cell surface receptor linked signal transduction; negative regulation of T cell proliferation; negative regulation of interleukin-10 production; negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; T cell costimulation; positive regulation of T cell proliferation; immune response; signal transduction; positive regulation of cell migration
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Research Articles on Cd274

1. In vivo blockade of PD-1/PD-L1 pathway on CD8 T cells, in combination with ETV treatment and DNA vaccination, potently enhanced the function of virus-specific T cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Cd274 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 PD-1 Signaling Pathway antibodies  PD-1 Signaling Pathway Diagram

Diseases associated with anti-Cd274 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >111 publications with Cd274 and Inflammation
 Liver Diseases Antibodies  >88 publications with Cd274 and Liver Diseases
 Necrosis Antibodies  >74 publications with Cd274 and Necrosis
 Neoplasms, Experimental Antibodies  >72 publications with Cd274 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >71 publications with Cd274 and Nervous System Diseases
 Adenocarcinoma Antibodies  >66 publications with Cd274 and Adenocarcinoma
 Lung Diseases Antibodies  >46 publications with Cd274 and Lung Diseases
 Lung Neoplasms Antibodies  >45 publications with Cd274 and Lung Neoplasms
 Kidney Diseases Antibodies  >44 publications with Cd274 and Kidney Diseases
 Recurrence Antibodies  >29 publications with Cd274 and Recurrence

Organs/Tissues associated with anti-Cd274 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >785 publications with Cd274 and Blood
 Lung Antibodies  >75 publications with Cd274 and Lung
 Spleen Antibodies  >64 publications with Cd274 and Spleen
 Bone Marrow Antibodies  >63 publications with Cd274 and Bone Marrow
 Skin Antibodies  >47 publications with Cd274 and Skin
 Pancreas Antibodies  >28 publications with Cd274 and Pancreas
 Heart Antibodies  >25 publications with Cd274 and Heart
 Stomach Antibodies  >13 publications with Cd274 and Stomach
 Uterus Antibodies  >7 publications with Cd274 and Uterus
 Thymus Antibodies  >6 publications with Cd274 and Thymus
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