TPD52 Antibody – Rabbit Polyclonal

TPD52: a coiled-coil motif bearing hydrophilic protein known to be overexpressed in many human solid tumors of diverse cellular origins. May be associated with B cell differentiation. Increased expression is associated with increased proliferation and invasive capacity in different cell types. May negatively regulate ATM protein levels. Isoform 2 is expressed in colon, breast, prostate, pancreas and kidney tumor cell lines. Isoform 2 is expressed at high levels in kidney, prostate, brain, small intestine and pancreas, at moderate levels in placenta and colon, at low levels in lung, liver and heart, and at very low levels in spleen, thymus, peripheral mononuclear blood cells, testis and ovary. Isoform 2 is expressed at lower levels in fetal brain and kidney than in adult brain and kidney. Eight isoforms of the human protein are produced by alternative splicing

Protein type: Endoplasmic reticulum; Calcium-binding

Chromosomal Location of Human Ortholog: 8q21.13

Cellular Component: perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm

Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; calcium ion binding

Biological Process: anatomical structure morphogenesis; secretion; B cell differentiation; positive regulation of cell proliferation