Rabbit Anti-PRAME Polyclonal Antibody – Cat# MBS847749

PRAME Antibody – Rabbit Polyclonal

Name: PRAME Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS847749
Price: 460 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847749

This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

PRAME, Polyclonal Antibody

Full Product Name

Anti-PRAME Antibody

Product Gene Name

anti-PRAME antibody

Product Synonym Names

OIP4; preferentially expressed antigen in melanoma; CT130; PRAME; OIP-4; MAPE

Clonality

Polyclonal

Isotype

Rabbit IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid. PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purity/Purification

Affinity purification

Preparation and Storage

Store at -20 degree C
The antibody solution should be gently mixed before use.
Shelf life: ~12 months

OMIM

606021

3D Structure

ModBase 3D Structure for P78395

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PRAME

Product Categories/Family for anti-PRAME antibody

Cancer Research; Tumor Biomarkers; Antibodies; Antibodies & Supporting Tools; Primary Antibodies (A-Z)

Applications Tested/Suitable for anti-PRAME antibody

Immunofluorescence (IF)

Application Notes for anti-PRAME antibody

WB: 1:500-1:2000
IF: 1:20-1:50

Other Notes

Small volumes of anti-PRAME antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRAME purchase

MBS847749 is an antibody targeting PRAME. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PRAME. It may not necessarily be applicable to this product.

NCBI GeneID

23532

NCBI Accession #

NP_996839.1

UniProt Primary Accession #

P78395

UniProt Protein Name

Melanoma antigen preferentially expressed in tumors

UniProt Synonym Protein Names

Opa-interacting protein 4; OIP-4; Preferentially expressed antigen of melanoma

Protein Family

Melanoma antigen

UniProt Gene Name

PRAME

UniProt Synonym Gene Names

MAPE; OIP4; OIP-4

UniProt Entry Name

PRAME_HUMAN

UniProt Comments for PRAME

PRAME: Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Belongs to the PRAME family.

Protein type: Nuclear receptor co-regulator; Cancer Testis Antigen (CTA); Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 22q11.22

Cellular Component: plasma membrane; nucleus

Molecular Function: protein binding; retinoic acid receptor binding

Biological Process: negative regulation of retinoic acid receptor signaling pathway; negative regulation of cell differentiation; transcription, DNA-dependent; apoptosis; regulation of growth; positive regulation of cell proliferation; cell differentiation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.