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SP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847817

The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses,… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
SP1, Polyclonal Antibody
Full Product Name
Anti-SP1 Antibody
Product Gene Name
anti-SP1 antibody
Product Synonym Names
TSFP1; Transcription factor Sp1
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Bovine, Rat, Chicken, Monkey, Mouse, Human
Form/Format
Colorless liquid. In 0.42% Potassium phosphate; 0.87% NaCl; pH7.3; 30% glycerol; and 0.01% sodium azide
Purity/Purification
Affinity purification
Specificity
Affinity purified rabbit polyclonal antibody to detect SP1 expression in human, mouse, rat, bovine, chicken and monkey samples
Preparation and Storage
Store at -20 degree C
The antibody solution should be gently mixed before use.
Shelf life: ~12 months
Molecular Weight
80,693 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (53773979..53810230). Location: 12q13.1
OMIM
189906
3D Structure
ModBase 3D Structure for P08047
Immunogen
KLH-conjugated synthetic peptide targeting a sequence within the center region of human SP1

Product Categories/Family for anti-SP1 antibody

Primary Antibodies; Diabetes; Obesity & Metabolic Syndrome; Signaling Pathways in Diabetes; Obesity; TGFbeta Signaling Antibodies; Stem Cell Research Tools; Stem Cell Signaling Pathways; TGFbeta; Smad Signaling Antibodies; Cancer Stem Cells; Signaling Pat
Applications Tested/Suitable for anti-SP1 antibody
Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-SP1 antibody
WB: 1:500-1:1000
IF: 1:100-1:500

Immunocytochemistry/Immunofluorescence (ICC/IF)) of anti-SP1 antibody

Rabbit Anti-SP1 Polyclonal Antibody – Cat# MBS847817

Western Blot (WB) of anti-SP1 antibody

Rabbit Anti-SP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS847817

Other Notes

Small volumes of anti-SP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SP1 purchase

MBS847817 is an antibody targeting SP1. Reactive in Bovine, Rat, Chicken, Monkey, Mouse, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SP1. It may not necessarily be applicable to this product.

NCBI GI #
352962149
NCBI GeneID
6667
NCBI Accession #
NP_001238754.1
UniProt Primary Accession #
P08047
UniProt Secondary Accession #
Q86TN8; Q9H3Q5; Q9NR51; Q9NY21; Q9NYE7
UniProt Related Accession #
P08047
GenBank Nucleotide #
NM_001251825.1
NCBI Official Full Name
transcription factor Sp1 isoform c
NCBI Official Synonym Full Names
Sp1 transcription factor
NCBI Official Symbol
SP1
UniProt Protein Name
Transcription factor Sp1
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
SP1
UniProt Synonym Gene Names
TSFP1
UniProt Entry Name
SP1_HUMAN
NCBI Protein Information
transcription factor Sp1; specificity protein 1

UniProt Comments for SP1

SP1: a transcription factor of the Sp1 C2H2-type zinc-finger protein family. Phosphorylated and activated by MAPK. Dephosphorylation by PTEN inhibits DNA binding. Binds to p38 in the nucleus. Interacts with Huntingtin and TAFII130. Transcriptional activity of SP1 and TAFII130 disrupted in early Huntingtin's Disease.

Protein type: DNA-binding; Transcription factor; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein C-terminus binding; histone acetyltransferase binding; protein binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; metal ion binding; histone deacetylase binding; double-stranded DNA binding; bHLH transcription factor binding; transcription factor binding; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; ossification; embryonic placenta development; transcription, DNA-dependent; viral reproduction; megakaryocyte differentiation; embryonic skeletal development; positive regulation of transcription, DNA-dependent; embryonic process involved in female pregnancy; rhythmic process; cellular lipid metabolic process; enucleate erythrocyte differentiation; liver development; trophectodermal cell differentiation; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; gene expression; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; lung development
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Research Articles on SP1

1. The present study identified a proximal core sequence in the MGARP promoter that is composed of two enriched Sp1 binding motifs and established Sp1 as one major MGARP transactivator.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SP1 antibody

 Reference Product  PubMed Publications
 JUN antibody  >1117 publications with SP1 and JUN
 MYC antibody  >264 publications with SP1 and MYC
 EGR1 antibody  >199 publications with SP1 and EGR1
 CDKN1A antibody  >195 publications with SP1 and CDKN1A
 SP4 antibody  >172 publications with SP1 and SP4
 YY1 antibody  >118 publications with SP1 and YY1
 TBP antibody  >98 publications with SP1 and TBP
 HDAC1 antibody  >96 publications with SP1 and HDAC1
 CCND1 antibody  >89 publications with SP1 and CCND1
 E2F1 antibody  >82 publications with SP1 and E2F1

Pathways associated with anti-SP1 antibody

 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activation Of Gene Expression By SREBP (SREBF) Pathway antibodies  Activation Of Gene Expression By SREBP (SREBF) Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram

Diseases associated with anti-SP1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1804 publications with SP1 and Neoplasms
 Breast Neoplasms Antibodies  >317 publications with SP1 and Breast Neoplasms
 Nervous System Diseases Antibodies  >254 publications with SP1 and Nervous System Diseases
 Necrosis Antibodies  >250 publications with SP1 and Necrosis
 Liver Diseases Antibodies  >249 publications with SP1 and Liver Diseases
 Inflammation Antibodies  >194 publications with SP1 and Inflammation
 Cardiovascular Diseases Antibodies  >192 publications with SP1 and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >192 publications with SP1 and Liver Neoplasms
 Disease Models, Animal Antibodies  >176 publications with SP1 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >176 publications with SP1 and Neoplasms, Experimental

Organs/Tissues associated with anti-SP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1170 publications with SP1 and Blood
 Liver Antibodies  >712 publications with SP1 and Liver
 Brain Antibodies  >595 publications with SP1 and Brain
 Vascular Antibodies  >542 publications with SP1 and Vascular
 Muscle Antibodies  >506 publications with SP1 and Muscle
 Lung Antibodies  >405 publications with SP1 and Lung
 Kidney Antibodies  >400 publications with SP1 and Kidney
 Bone Antibodies  >300 publications with SP1 and Bone
 Heart Antibodies  >278 publications with SP1 and Heart
 Placenta Antibodies  >265 publications with SP1 and Placenta
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