• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

IgG, Kappa (TIGIT) Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847835

Recombinant monoclonal antibody to TIGIT. T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as VSTM3, is a type I transmembrane protein, which belongs to the PVR family of immunoglobulin-like domain containing proteins. It is composed of an… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
TIGIT, IgG, kappa, Monoclonal Antibody
Full Product Name
Anti-TIGIT, Rabbit IgG, kappa Antibody
Product Gene Name
Product Synonym Names
T Cell Immunoreceptor With Ig And ITIM Domains; V-Set And Immunoglobulin Domain Containing Protein 9; V-Set And Transmembrane Domain Containing Protein 3; VSIG9; VSTM3; T Cell Immunoreceptor With Ig And ITIM Domains; Washington University Cell Adhesion Molecule; WUCAM
Clonality
Monoclonal
Isotype
Rabbit IgG, kappa
Clone Number
4D4
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Colorless liquid. In PBS with 0.02% Proclin 300
Purity/Purification
Protein A purification
Concentration
1mg/ml (lot specific)
Specificity
Recombinant monoclonal antibody manufactured using Recombinant Platform with variable regions from the hybridoma 4D4 to detect TIGIT expression in mouse. 4D4 is an agonistic anti-TIGIT antibody, and addition of anti-CD3/anti-CD28 stimulated T cells to plate bound 4D4 is known to inhibit their proliferation. Further, 4D4 has been used in order to identify genes that are downstream of TIGIT signaling in Tregs, as TIGIT engagement might modulate the Treg phenotype in tumor tissue.
Preparation and Storage
Store at -20 degree C
The antibody solution should be gently mixed before use.
Shelf life: ~12 months
Molecular Weight
26,959 Da
3D Structure
ModBase 3D Structure for P86176
Antibody Type
Recombinant Antibody
Immunogen
Armenian hamsters were immunized with recombinant mouse TIGIT tetramers by a combination of s.c. and food pad immunization and booster injections. Draining lymph nodes were fused with Sp2/0-Ag14 cells, selected in HAT medium and supernatants were screened for specificity by ELISA and FC using TIGIT-transfectants
Applications Tested/Suitable for anti-TIGIT antibody
Agonist, Flow Cytometry (FC/FACS)

ELISA (EIA) of anti-TIGIT antibody

Rabbit Anti-TIGIT Monoclonal Antibody – Cat# MBS847835

Other Notes

Small volumes of anti-TIGIT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TIGIT purchase

MBS847835 is an antibody targeting TIGIT. Also known as Anti-TIGIT, Rabbit IgG, kappa Antibody. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TIGIT. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
T-cell immunoreceptor with Ig and ITIM domains
NCBI Official Synonym Full Names
T cell immunoreceptor with Ig and ITIM domains
NCBI Official Symbol
Tigit
NCBI Official Synonym Symbols
Vstm3
UniProt Protein Name
T-cell immunoreceptor with Ig and ITIM domains
UniProt Synonym Protein Names
V-set and transmembrane domain-containing protein 3
UniProt Gene Name
Tigit
NCBI Protein Information
T-cell immunoreceptor with Ig and ITIM domains

UniProt Comments for TIGIT

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000