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GDC-0623

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848051

GDC-0623 is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM) . More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GDC-0623, Biochemical
Full Product Name
GDC-0623
Product Synonym Names
GDC-0623; GDC0623; GDC 0623; 5- (2-fluoro-4-iodoanilino)-N- (2-hydroxyethoxy) imidazo[1; 5-a]pyridine-6-carboxamide
Form/Format
Solid powder
Purity/Purification
>98%
Preparation and Storage
Store at -20 degree C
Protect from air and light
Shelf life: ~36 months
Molecular Weight
456.21
Solubility
DMSO
Molecular Formula
C??H??FIN?O?
CAS Number
1168091-68-6
PubChem CID
42642654
SMILES
C1=CC (=C (C=C1I)F)NC2=C (C=CC3=CN=CN32)C (=O)NOCCO
InChi
InChI=1S/C16H14FIN4O3/c17-13-7-10 (18)1-4-14 (13)20-15-12 (16 (24)21-25-6-5-23)3-2-11-8-19-9-22 (11)15/h1-4,7-9,20,23H,5-6H2, (H,21,24)
InChi Key
RFWVETIZUQEJEF-UHFFFAOYSA-N

Product Categories/Family for GDC-0623 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; MAP Kinase; MEK Inhibitors; Signaling Pathways; MAP Kinase Pathway; Biochemicals; Biochemicals (A-Z)

Structure of GDC-0623 biochemical

GDC-0623 Biochemical – Cat# MBS848051

Product References and Citations for GDC-0623 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/42642654

Other Notes

Small volumes of GDC-0623 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDC-0623 purchase

MBS848051 is a biochemical targeting GDC-0623.
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