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Pexmetinib

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848070

Pexmetinib (ARRY-614) is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Pexmetinib, Biochemical
Full Product Name
Pexmetinib
Product Synonym Names
Pexmetinib; ARRY-614; ARRY614; ARRY 614; (Z)-N- (3- (tert-butyl)-1- (p-tolyl)-1H-pyrazol-5-yl)-N'- (5-fluoro-2- ( (1- (2-hydroxyethyl)-1H-indazol-5-yl) oxy) benzyl) carbamimidic acid; 1-[5-tert-butyl-2- (4-methylphenyl) pyrazol-3-yl]-3-[[5-fluoro-2-[1- (2-hydroxyethyl) indazol-5-yl]oxyphenyl]methyl]urea; 1- (3- (tert-butyl)-1- (p-tolyl)-1H-pyrazol-5-yl)-3- (5-fluoro-2- ( (1- (2-hydroxyethyl)-1H-indazol-5-yl) oxy) benzyl) urea
Form/Format
Solid powder
Purity/Purification
>98%
Preparation and Storage
Store at -20 degree C
Protect from air and light
Shelf life: ~36 months
Molecular Weight
556.63
Solubility
DMSO
Molecular Formula
C??H??FN?O?
CAS Number
945614-12-0
PubChem CID
24765037
SMILES
CC1=CC=C (C=C1)N2C (=CC (=N2)C (C)(C)C)NC (=O)NCC3=C (C=CC (=C3)F)OC4=CC5=C (C=C4)N (N=C5)CCO
InChi
InChI=1S/C31H33FN6O3/c1-20-5-8-24 (9-6-20)38-29 (17-28 (36-38)31 (2,3)4)35-30 (40)33-18-22-15-23 (32)7-12-27 (22)41-25-10-11-26-21 (16-25)19-34-37 (26)13-14-39/h5-12,15-17,19,39H,13-14,18H2,1-4H3, (H2,33,35,40)
InChi Key
LNMRSSIMGCDUTP-UHFFFAOYSA-N

Product Categories/Family for Pexmetinib biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Casein kinase (CK) Inhibitors; Enzyme Inhibitors (A-Z); Biochemicals; Biochemicals (A-Z)

Structure of Pexmetinib biochemical

Pexmetinib Biochemical – Cat# MBS848070

Product References and Citations for Pexmetinib biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/24765037#section=Top

Other Notes

Small volumes of Pexmetinib biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Pexmetinib purchase

MBS848070 is a biochemical targeting Pexmetinib.
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