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GDC-0349

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848084

GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki value of 3.8 nM. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GDC-0349, Biochemical
Full Product Name
GDC-0349
Product Synonym Names
GDC-0349; GDC0349; GDC 0349; RG7603; 1-ethyl-3-[4-[4-[ (3S)-3-methylmorpholin-4-yl]-7- (oxetan-3-yl)-6; 8-dihydro-5H-pyrido[3; 4-d]pyrimidin-2-yl]phenyl]urea; (S)-1-ethyl-3- (4- (4- (3-methylmorpholino)-7- (oxetan-3-yl)-5; 6; 7; 8-tetrahydropyrido[3; 4-d]pyrimidin-2-yl) phenyl) urea
Form/Format
Solid powder
Purity/Purification
>98%
Preparation and Storage
Store at -20 degree C
Protect from air and light
Shelf life: ~36 months
Molecular Weight
452.55
Solubility
DMSO
Molecular Formula
C??H??N?O?
CAS Number
1207360-89-1
MDL Number
MFCD22417087
PubChem CID
59239165
SMILES
CCNC (=O)NC1=CC=C (C=C1)C2=NC3=C (CCN (C3)C4COC4)C (=N2)N5CCOCC5C
InChi
InChI=1S/C24H32N6O3/c1-3-25-24 (31)26-18-6-4-17 (5-7-18)22-27-21-12-29 (19-14-33-15-19)9-8-20 (21)23 (28-22)30-10-11-32-13-16 (30)2/h4-7,16,19H,3,8-15H2,1-2H3, (H2,25,26,31)/t16-/m0/s1
InChi Key
RGJOJUGRHPQXGF-INIZCTEOSA-N

Product Categories/Family for GDC-0349 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; PI3K; mTOR Inhibitors; Signaling Pathways; Akt; mTOR Signaling; Inhibitors; Biochemicals; Biochemicals (A-Z)

Structure of GDC-0349 biochemical

GDC-0349 Biochemical – Cat# MBS848084

Product References and Citations for GDC-0349 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/59239165#section=Top

Other Notes

Small volumes of GDC-0349 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDC-0349 purchase

MBS848084 is a biochemical targeting GDC-0349.
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