RO8994 ((2'S)

Name: RO8994 ((2'S); MyBioSource
Brand: MyBioSource
SKU: MBS848128
Price: 400 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848128

RO8994 is a highly potent and selective spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays) . More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

RO8994, Biochemical

Full Product Name

RO8994

Product Synonym Names

(2'S; 3R; 4'R; 5'R)-N- (4-carbamoyl-2-methoxyphenyl)-6-chloro-4'- (3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3; 3'-pyrrolidine]-5'-carboxamide

Form/Format

Crystalline solid

Purity/Purification

>=98% by HPLC

Preparation and Storage

Store at -20 degree C
Protect from air and light
Shelf life: ~36 months

Molecular Weight

613.51

Solubility

DMSO

Molecular Formula

C??H??Cl?FN?O?

CAS Number

1309684-94-3

PubChem CID

53238217

SMILES

CC (C)(C)CC1C2 (C (C (N1)C (=O)NC3=C (C=C (C=C3)C (=O)N)OC)C4=C (C (=CC=C4)Cl)F)C5=C (C=C (C=C5)Cl)NC2=O

InChi

InChI=1S/C31H31Cl2FN4O4/c1-30 (2,3)14-23-31 (18-10-9-16 (32)13-21 (18)37-29 (31)41)24 (17-6-5-7-19 (33)25 (17)34)26 (38-23)28 (40)36-20-11-8-15 (27 (35)39)12-22 (20)42-4/h5-13,23-24,26,38H,14H2,1-4H3, (H2,35,39)(H,36,40)(H,37,41)/t23-,24-,26+,31+/m0/s1

InChi Key

MURAVORBGFDSMA-ISKXDESKSA-N

Product Categories/Family for RO8994 biochemical

Enzyme Inhibitors; MDM2 Inhibitors; Enzyme Inhibitors; Enzyme Inhibitors (A-Z); Biochemicals; Biochemicals (A-Z)

Product References and Citations for RO8994 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/53238217

Other Notes

Small volumes of RO8994 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RO8994 purchase

MBS848128 is a biochemical targeting RO8994.