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NVS-SM1

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848142

NVS-SM1, also known as LMI070, is a highly potent, selective small molecule SMN2 splicing modulator with potential for treating spinal muscular atrophy. It works by increasing the amount of functional survival of motor neuron protein produced by the SMN2… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
NVS-SM1, Biochemical
Full Product Name
NVS-SM1
Product Synonym Names
(6Z)-3- (1H-pyrazol-4-yl)-6-[3- (2; 2; 6; 6-tetramethylpiperidin-4-yl) oxy-1H-pyridazin-6-ylidene]cyclohexa-2; 4-dien-1-one; Branaplam; LMI070
Form/Format
Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Protect from air and light
Shelf life: ~36 months
Molecular Weight
393.49
Solubility
DMSO
Molecular Formula
C??H??N?O?
CAS Number
1562338-42-4
PubChem CID
89971189
SMILES
CC1 (CC (CC (N1)(C)C)OC2=NNC (=C3C=CC (=CC3=O)C4=CNN=C4)C=C2)C
InChi
InChI=1S/C22H27N5O2/c1-21 (2)10-16 (11-22 (3,4)27-21)29-20-8-7-18 (25-26-20)17-6-5-14 (9-19 (17)28)15-12-23-24-13-15/h5-9,12-13,16,25,27H,10-11H2,1-4H3, (H,23,24)/b18-17+
InChi Key
YIFFDXMJVNKGBL-ISLYRVAYSA-N

Product Categories/Family for NVS-SM1 biochemical

Enzyme Inhibitors; Other Inhibitors; Enzyme Inhibitors (A-Z); Antiviral Agents; Biochemicals; Biochemicals (A-Z)

Structure of NVS-SM1 biochemical

NVS-SM1 Biochemical – Cat# MBS848142

Product References and Citations for NVS-SM1 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/89971189

Other Notes

Small volumes of NVS-SM1 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NVS-SM1 purchase

MBS848142 is a biochemical targeting NVS-SM1.
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