Tropodithietic Acid (3-Oxo-8)

Tropodithietic acid is a broad spectrum tropolone antibiotic with activity against both Gram-negative and Gram-positive bacteria. Displays cytotoxic effects on mammalian cell lines (neuronal N2a cells and OLN-93 cells as model systems for nerve cells and glia) acting via disruption of mitochondrial membrane potential, activation of ERK1/2 and induction of HSP32/HO-1 (considered as a sensor of oxidative stress). A broad-spectrum antibiotic agent produced by marine bacteria which does not appear to induce resistance after long-term exposure.

https://pubchem.ncbi.nlm.nih.gov/compound/44632924

Small volumes of Tropodithietic Acid biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS848165 is a biochemical targeting Tropodithietic Acid.