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FRAX597

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848188

FRAX597 is a potent group I PAK (p21-activated kinase) inhibitor (IC50 values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively). Displays significant inhibition of YES1, RET, CSF1R and TEK at 100 nM, but is inactive against group II PAK isoforms… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
FRAX597, Biochemical
Full Product Name
FRAX597
Product Synonym Names
6-[2-Chloro-4- (5-thiazolyl) phenyl]-8-ethyl-2-[[4- (4-methyl-1-piperazinyl) phenyl]amino]pyrido[2; 3-d]pyrimidin-7- (8H)-one
Form/Format
Yellow solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Protect from air and light
Shelf life: ~36 months
Molecular Weight
558.1
Solubility
DMSO (>5 mg/ml)
Molecular Formula
C??H??ClN?OS
CAS Number
1286739-19-2
PubChem CID
70934541
SMILES
CCN1C2=NC (=NC=C2C=C (C1=O)C3=C (C=C (C=C3)C4=CN=CS4)Cl)NC5=CC=C (C=C5)N6CCN (CC6)C
InChi
InChI=1S/C29H28ClN7OS/c1-3-37-27-20 (14-24 (28 (37)38)23-9-4-19 (15-25 (23)30)26-17-31-18-39-26)16-32-29 (34-27)33-21-5-7-22 (8-6-21)36-12-10-35 (2)11-13-36/h4-9,14-18H,3,10-13H2,1-2H3, (H,32,33,34)
InChi Key
DHUJCQOUWQMVCG-UHFFFAOYSA-N

Product Categories/Family for FRAX597 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Other Protein Kinase Inhibitors; Enzyme Inhibitors (A-Z); Biochemicals; Biochemicals (A-Z)

Structure of FRAX597 biochemical

FRAX597 Biochemical – Cat# MBS848188

Product References and Citations for FRAX597 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/70934541

Other Notes

Small volumes of FRAX597 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FRAX597 purchase

MBS848188 is a biochemical targeting FRAX597.
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