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AZD-9291 mesylate

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848197

AZD9291 is a potent, selective, and irreversible, third generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). It inhibits EGFR phosphorylation in EGFR-bearing cells harboring sensitizing EGFR mutants with mean IC50 values ranging… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
AZD-9291 mesylate, Biochemical
Full Product Name
AZD-9291 mesylate
Product Synonym Names
(Z)-N- (2- ( (2- (dimethylamino) ethyl) (methyl) amino)-4-methoxy-5- ( (4- (1-methyl-1H-indol-3-yl) pyrimidin-2-yl) amino) phenyl) acrylimidic acid methnanesulfonic acid; Osimertinib; methanesulfonate
Form/Format
Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Protect from air and light
Shelf life: ~36 months
Molecular Weight
595.71
Solubility
DMSO
Molecular Formula
C??H??N?O?S
CAS Number
1421373-66-1
PubChem CID
78357807
SMILES
CN1C=C (C2=CC=CC=C21)C3=NC (=NC=C3)NC4=C (C=C (C (=C4)NC (=O)C=C)N (C)CCN (C)C)OC.CS (=O)(=O)O
InChi
InChI=1S/C28H33N7O2.CH4O3S/c1-7-27 (36)30-22-16-23 (26 (37-6)17-25 (22)34 (4)15-14-33 (2)3)32-28-29-13-12-21 (31-28)20-18-35 (5)24-11-9-8-10-19 (20)24;1-5 (2,3)4/h7-13,16-18H,1,14-15H2,2-6H3, (H,30,36)(H,29,31,32);1H3, (H,2,3,4)
InChi Key
FUKSNUHSJBTCFJ-UHFFFAOYSA-N

Product Categories/Family for AZD-9291 mesylate biochemical

Products; Signaling Pathways; EGFR Signaling EGFR Inhibitors; Biochemicals; Biochemicals (A-Z)

Structure of AZD-9291 mesylate biochemical

AZD-9291 mesylate Biochemical – Cat# MBS848197

Product References and Citations for AZD-9291 mesylate biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/78357807

Other Notes

Small volumes of AZD-9291 mesylate biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AZD-9291 mesylate purchase

MBS848197 is a biochemical targeting AZD-9291 mesylate.
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