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trans-ISRIB

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848204

trans-ISRIB is an integrated stress response inhibitor. Potently reverses the effects of initiation factor 2alpha (eIF2alpha) phosphorylation (IC50 = 5 nM). Enhances spatial and fear-associated learning in mice and enhances cognitive function. Mechanism of… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
trans-ISRIB, Biochemical
Full Product Name
trans-ISRIB
Product Synonym Names
N; N'-trans-1; 4-cyclohexanediylbis[2- (4-chlorophenoxy) acetamide]; ISRIB
Form/Format
White solid
Purity/Purification
>=98% by TLC
Preparation and Storage
Store at -20 degree C
Protect from air and light
Shelf life: ~36 months
Molecular Weight
451.3
Solubility
DMSO (~ 5 mg/ml)
Molecular Formula
C??H??Cl?N2?O?
CAS Number
1597403-47-8
PubChem CID
1011240
SMILES
C1CC (CCC1NC (=O)COC2=CC=C (C=C2)Cl)NC (=O)COC3=CC=C (C=C3)Cl
InChi
InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19 (10-2-15)29-13-21 (27)25-17-5-7-18 (8-6-17)26-22 (28)14-30-20-11-3-16 (24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2, (H,25,27)(H,26,28)
InChi Key
HJGMCDHQPXTGAV-UHFFFAOYSA-N

Product Categories/Family for trans-ISRIB biochemical

Enzyme Inhibitors; Other Inhibitors; Enzyme Inhibitors (A-Z); Antiviral Agents; Biochemicals; Biochemicals (A-Z)

Structure of trans-ISRIB biochemical

Trans-ISRIB Biochemical – Cat# MBS848204

Product References and Citations for trans-ISRIB biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/1011240

Other Notes

Small volumes of trans-ISRIB biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for trans-ISRIB purchase

MBS848204 is a biochemical targeting trans-ISRIB.
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