FPS-ZM1

FPS-ZM1 is a high-affinity, brain-permeable, RAGE (Receptor for Advanced Glycation End products) receptor antagonist (Ki = 25 nM). It lowers levels of Abeta via binding to the V domain of RAGE and can block multiple mechanisms of Abeta40- and Abeta42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivo. In a rat model of intracerebral hemorrhage, FPS-ZM1 attenuates blood-brain barrier and white matter fiber damage. It ameliorates inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1 (HMGB1) signaling.

https://pubchem.ncbi.nlm.nih.gov/compound/24752728

Small volumes of FPS-ZM1 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS848231 is a biochemical targeting FPS-ZM1.