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GSK-1070916

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848237

GSK-1070916 is a potent, reversible and ATP-competitive inhibitor of Aurora kinases B and C with IC50 value of 3.5 nM and 6.5 nM, respectively. Treatment of GSK-1070916 suppresses cell proliferation in A549 human lung cancer cells with EC50 value of 7 nM. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GSK-1070916, Biochemical
Full Product Name
GSK-1070916
Product Synonym Names
3-[4-[4-[2-[3-[ (dimethylamino) methyl]phenyl]-1H-pyrrolo[2; 3-b]pyridin-4-yl]-1-ethylpyrazol-3-yl]phenyl]-1; 1-dimethylurea
Form/Format
Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Protect from air and light
Shelf life: ~36 months
Molecular Weight
507.63
Solubility
DMSO (>25 mg/ml)
Molecular Formula
C??H??N?O
CAS Number
942918-07-2
PubChem CID
46885626
SMILES
CCN1C=C (C (=N1)C2=CC=C (C=C2)NC (=O)N (C)C)C3=C4C=C (NC4=NC=C3)C5=CC (=CC=C5)CN (C)C
InChi
InChI=1S/C30H33N7O/c1-6-37-19-26 (28 (34-37)21-10-12-23 (13-11-21)32-30 (38)36 (4)5)24-14-15-31-29-25 (24)17-27 (33-29)22-9-7-8-20 (16-22)18-35 (2)3/h7-17,19H,6,18H2,1-5H3, (H,31,33)(H,32,38)
InChi Key
QTBWCSQGBMPECM-UHFFFAOYSA-N

Product Categories/Family for GSK-1070916 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Aurora Kinase Inhibitors; Enzyme Inhibitors (A-Z); Biochemicals (A-Z)

Structure of GSK-1070916 biochemical

GSK-1070916 Biochemical – Cat# MBS848237

Product References and Citations for GSK-1070916 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/46885626

Other Notes

Small volumes of GSK-1070916 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK-1070916 purchase

MBS848237 is a biochemical targeting GSK-1070916.
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