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MK-8745

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848240

MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
MK-8745, Biochemical
Full Product Name
MK-8745
Product Synonym Names
(3-chloro-2-fluorophenyl) (4- ( (6- (thiazol-2-ylamino) pyridin-2-yl) methyl) piperazin-1-yl) methanone
Form/Format
Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Protect from air and light
Shelf life: ~36 months
Molecular Weight
431.91
Solubility
DMSO (>18 mg/ml)
Molecular Formula
C??H??ClFN?OS
CAS Number
885325-71-3
PubChem CID
11676373
SMILES
C1CN (CCN1CC2=NC (=CC=C2)NC3=NC=CS3)C (=O)C4=C (C (=CC=C4)Cl)F
InChi
InChI=1S/C20H19ClFN5OS/c21-16-5-2-4-15 (18 (16)22)19 (28)27-10-8-26 (9-11-27)13-14-3-1-6-17 (24-14)25-20-23-7-12-29-20/h1-7,12H,8-11,13H2, (H,23,24,25)
InChi Key
YCRFPWKUUNKNDN-UHFFFAOYSA-N

Product Categories/Family for MK-8745 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Aurora Kinase Inhibitors; Enzyme Inhibitors (A-Z); Biochemicals (A-Z)

Structure of MK-8745 biochemical

Mk-8745 Biochemical – Cat# MBS848240

Product References and Citations for MK-8745 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/11676373

Other Notes

Small volumes of MK-8745 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MK-8745 purchase

MBS848240 is a biochemical targeting MK-8745.
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