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AMG-925

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848257

AMG-925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively. It inhibits the proliferation of a panel of human tumor cell lines including Colo205 (Rb (+) ) and U937 (FLT3 (WT) ) and induces cell death in… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
AMG-925, Biochemical
Full Product Name
AMG-925
Product Synonym Names
2-hydroxy-1-[2-[[9- (4-methylcyclohexyl) pyrido[4; 5]pyrrolo[1; 2-d]pyrimidin-2-yl]amino]-7; 8-dihydro-5H-1; 6-naphthyridin-6-yl]ethenone
Form/Format
Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Protect from air and light
Shelf life: ~36 months
Molecular Weight
471.55
Solubility
DMSO
Molecular Formula
C??H??N?O?
CAS Number
1401033-86-0
PubChem CID
60202647
SMILES
CC1CCC (CC1)N2C3=C (C=CN=C3)C4=CN=C (N=C42)NC5=NC6=C (CN (CC6)C (=O)CO)C=C5
InChi
InChI=1S/C26H29N7O2/c1-16-2-5-18 (6-3-16)33-22-13-27-10-8-19 (22)20-12-28-26 (31-25 (20)33)30-23-7-4-17-14-32 (24 (35)15-34)11-9-21 (17)29-23/h4,7-8,10,12-13,16,18,34H,2-3,5-6,9,11,14-15H2,1H3, (H,28,29,30,31)
InChi Key
BBUVDDPUURMFOX-UHFFFAOYSA-N

Product Categories/Family for AMG-925 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase Inhibitors; CDK4 Inhibitors; Enzyme Inhibitors (A-Z); Biochemicals; Biochemicals (A-Z)

Structure of AMG-925 biochemical

AMG-925 Biochemical – Cat# MBS848257

Product References and Citations for AMG-925 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/60202647

Other Notes

Small volumes of AMG-925 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AMG-925 purchase

MBS848257 is a biochemical targeting AMG-925.
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