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MK-0752

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848275

MK-0752 is a potent and reversible inhibitor of gamma-secretase, reducing the cleavage of APP to Abeta40 in human neuroblastoma SH-SY5Y cells (IC50 = 5 nM). Through its effects on the Notch pathway, MK-0752 reduces the number of breast cancer stem cells in… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
MK-0752, Biochemical
Full Product Name
MK-0752
Product Synonym Names
3-[4- (4-chlorophenyl) sulfonyl-4- (2; 5-difluorophenyl) cyclohexyl]propanoic acid
Form/Format
Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Protect from air and light
Shelf life: ~36 months
Molecular Weight
442.9
Solubility
DMSO (>20 mg/ml)
Molecular Formula
C??H??ClF?O?S
CAS Number
471905-41-6
PubChem CID
9803433
SMILES
C1CC (CCC1CCC (=O)O)(C2=C (C=CC (=C2)F)F)S (=O)(=O)C3=CC=C (C=C3)Cl
InChi
InChI=1S/C21H21ClF2O4S/c22-15-2-5-17 (6-3-15)29 (27,28)21 (18-13-16 (23)4-7-19 (18)24)11-9-14 (10-12-21)1-8-20 (25)26/h2-7,13-14H,1,8-12H2, (H,25,26)
InChi Key
XCGJIFAKUZNNOR-UHFFFAOYSA-N

Product Categories/Family for MK-0752 biochemical

Enzyme Inhibitors; Secretase Inhibitors Enzyme Inhibitors; Enzyme Inhibitors (A-Z); Biochemicals; Biochemicals (A-Z)

Structure of MK-0752 biochemical

Mk-0752 Biochemical – Cat# MBS848275

Product References and Citations for MK-0752 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/9803433

Other Notes

Small volumes of MK-0752 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MK-0752 purchase

MBS848275 is a biochemical targeting MK-0752.
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