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GSK-1838705A

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848319

GSK-1838705A is a potent small-molecule kinase inhibitor that inhibits IGF-IR and IR (insulin receptor) with IC50s of 2.0 and 1.6 nM, respectively. It also inhibits anaplastic lymphoma kinase (ALK). It causes complete regression of ALK-dependent tumors in… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
GSK-1838705A, Biochemical
Full Product Name
GSK-1838705A
Product Synonym Names
2- ( (2- ( (1- (2- (dimethylamino) acetyl)-5-methoxyindolin-6-yl) amino)-7H-pyrrolo[2; 3-d]pyrimidin-4-yl) amino)-6-fluoro-N-methylbenzamide
Form/Format
Beige solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Protect from air and light
Shelf life: ~36 months
Molecular Weight
532.57
Solubility
DMSO (>15 mg/ml)
Molecular Formula
C??H??FN?O?
CAS Number
1116235-97-2 
PubChem CID
25182616
SMILES
CNC (=O)C1=C (C=CC=C1F)NC2=NC (=NC3=C2C=CN3)NC4=C (C=C5CCN (C5=C4)C (=O)CN (C)C)OC
InChi
InChI=1S/C27H29FN8O3/c1-29-26 (38)23-17 (28)6-5-7-18 (23)31-25-16-8-10-30-24 (16)33-27 (34-25)32-19-13-20-15 (12-21 (19)39-4)9-11-36 (20)22 (37)14-35 (2)3/h5-8,10,12-13H,9,11,14H2,1-4H3, (H,29,38)(H3,30,31,32,33,34)
InChi Key
HZTYDQRUAWIZRE-UHFFFAOYSA-N

Product Categories/Family for GSK-1838705A biochemical

Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; ALK (Anaplastic Lymphoma Kinase) Inhibitors; Enzyme Inhibitors (A-Z); Protein Kinase Inhibitors (A-Z); Biochemicals (A-Z)

Structure of GSK-1838705A biochemical

GSK-1838705A Biochemical – Cat# MBS848319

Product References and Citations for GSK-1838705A biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/25182616

Other Notes

Small volumes of GSK-1838705A biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK-1838705A purchase

MBS848319 is a biochemical targeting GSK-1838705A.
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