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GDC-0853

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848364

GDC-0853 is a potent and selective, Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. GDC-0853 suppresses B cell- and myeloid cell-mediated components of disease and demonstrates dose-dependent activity in an in vivo rat model… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GDC-0853, Biochemical
Full Product Name
GDC-0853
Product Synonym Names
(S)-2- (3'- (hydroxymethyl)-1-methyl-5- ( (5- (2-methyl-4- (oxetan-3-yl) piperazin-1-yl) pyridin-2-yl) amino)-6-oxo-1; 6-dihydro-[3; 4'-bipyridin]-2'-yl)-7; 7-dimethyl-3; 4; 7; 8-tetrahydro-2H-cyclopenta[4; 5]pyrrolo[1; 2-a]pyrazin-1 (6H)-one
Form/Format
White to off-white solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Protect from air and light
Shelf life: ~36 months
Molecular Weight
664.81
Solubility
DMSO
Molecular Formula
C??H??N?O?
CAS Number
1434048-34-6
PubChem CID
86567195
SMILES
CC1CN (CCN1C2=CN=C (C=C2)NC3=CC (=CN (C3=O)C)C4=C (C (=NC=C4)N5CCN6C7=C (CC (C7)(C)C)C=C6C5=O)CO)C8COC8
InChi
InChI=1S/C37H44N8O4/c1-23-18-42 (27-21-49-22-27)9-10-43 (23)26-5-6-33 (39-17-26)40-30-13-25 (19-41 (4)35 (30)47)28-7-8-38-34 (29 (28)20-46)45-12-11-44-31 (36 (45)48)14-24-15-37 (2,3)16-32 (24)44/h5-8,13-14,17,19,23,27,46H,9-12,15-16,18,20-22H2,1-4H3, (H,39,40)/t23-/m0/s1
InChi Key
WNEODWDFDXWOLU-QHCPKHFHSA-N

Product Categories/Family for GDC-0853 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Bruton's Tyrosine Kinase (BTK) Inhibitors; Enzyme Inhibitors (A-Z); Biochemicals; Biochemicals (A-Z)

Structure of GDC-0853 biochemical

GDC-0853 Biochemical – Cat# MBS848364

Product References and Citations for GDC-0853 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/86567195

Other Notes

Small volumes of GDC-0853 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDC-0853 purchase

MBS848364 is a biochemical targeting GDC-0853.
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