Cx-5461 (2- (4-methyl-1)

Name: Cx-5461 (2- (4-methyl-1); MyBioSource
Brand: MyBioSource
SKU: MBS848463
Price: 205 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848463

CX-5461 is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 >=25 uM). At 50 mg/kg, CX-5461… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CX-5461, Biochemical

Full Product Name

CX-5461

Product Synonym Names

2- (4-methyl-1; 4-diazepan-1-yl)-N- ( (5-methylpyrazin-2-yl) methyl)-5-oxo-5H-benzo[4; 5]thiazolo[3; 2-a][1; 8]naphthyridine-6-carboxamide

Form/Format

Crystalline solid

Purity/Purification

>=98% by HPLC

Preparation and Storage

Store at -20 degree C
Protect from air and light
Shelf life: ~36 months

Molecular Weight

513.61

Solubility

DMSO

Molecular Formula

C??H??N?O?S

CAS Number

1138549-36-6

PubChem CID

25257557

SMILES

CC1=CN=C (C=N1)CNC (=O)C2=C3N (C4=CC=CC=C4S3)C5=C (C2=O)C=CC (=N5)N6CCCN (CC6)C

InChi

InChI=1S/C27H27N7O2S/c1-17-14-29-18 (15-28-17)16-30-26 (36)23-24 (35)19-8-9-22 (33-11-5-10-32 (2)12-13-33)31-25 (19)34-20-6-3-4-7-21 (20)37-27 (23)34/h3-4,6-9,14-15H,5,10-13,16H2,1-2H3, (H,30,36)

InChi Key

XGPBJCHFROADCK-UHFFFAOYSA-N

Product Categories/Family for CX-5461 biochemical

Biochemicals; Enzyme Inhibitors; Other Inhibitors; Enzyme Inhibitors (A-Z); Biochemicals (A-Z)

Product References and Citations for CX-5461 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/25257557

Other Notes

Small volumes of CX-5461 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CX-5461 purchase

MBS848463 is a biochemical targeting CX-5461.