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PF-477736

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848611

PF-477736 is a potent, ATP-competitive inhibitor of Chk1 (checkpoint kinase 1) (Ki =0.49 nM). It displays 100-fold selectivity over Chk2. PF-477736 abrogates DNA damage-induced cell cycle arrest. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PF-477736, Biochemical
Full Product Name
PF-477736
Product Synonym Names
(R)-alpha-Amino-N-[5; 6-dihydro-2- (1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4; 3; 2-ef][2; 3]benzodiazepin-8-yl]-cyclohexaneacetamide
Form/Format
Yellow solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Molecular Weight
419.48
Solubility
>30 mg/ml (DMSO)
Molecular Formula
C??H??N?O?
CAS Number
952021-60-2
MDL Number
MFCD16038847
PubChem CID
16750408
SMILES
CN1C=C (C=N1)C2=NC3=C4C2=CNNC (=O)C4=CC (=C3)NC (=O)C (C5CCCCC5)N
InChi
InChI=1S/C22H25N7O2/c1-29-11-13 (9-25-29)20-16-10-24-28-21 (30)15-7-14 (8-17 (27-20)18 (15
InChi Key
YFNWWNRZJGMDBR-LJQANCHMSA-N

Product Categories/Family for PF-477736 biochemical

Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Chk Kinase Inhibitors; Protein Kinase Inhibitors; Protein Kinase Inhibitors  (A-Z); Enzyme Inhibitors (A-Z); Biochemicals; Biochemicals (A-Z)

Structure of PF-477736 biochemical

Pf-477736 Biochemical – Cat# MBS848611

Product References and Citations for PF-477736 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/16750408#section=Top

Other Notes

Small volumes of PF-477736 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PF-477736 purchase

MBS848611 is a biochemical targeting PF-477736.
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