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BMS-986142

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848696

BMS-986142 is a potent, selective, and reversible BTK (Bruton's tyrosine kinase) inhibitor (BTK IC50 = 0.5nM; human WB IC50 = 90 nM). BMS-986142 displays robust efficacy in murine models of rheumatoid arthritis (RA), including collagen-induced arthritis (CIA)… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
BMS-986142, Biochemical
Full Product Name
BMS-986142
Product Synonym Names
BMS986142; (2S; 5R; 3S)-6-fluoro-5- (3- (8-fluoro-1-methyl-2; 4-dioxo-1; 4-dihydroquinazolin-3 (2H)-yl)-2-methylphenyl)-2- (2-hydroxypropan-2-yl)-2; 3; 4; 9-tetrahydro-1H-carbazole-8-carboxamide
Form/Format
White to off-white solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Molecular Weight
572.61
Solubility
>40 mg/ml DMSO
Molecular Formula
C??H??F?N?O?
CAS Number
1643368-58-4
PubChem CID
86582336
SMILES
CC1=C (C=CC=C1N2C (=O)C3=C (C (=CC=C3)F)N (C2=O)C)C4=C (C=C (C5=C4C6=C (N5)CC (CC6)C (C)(C)O)C (=O)N)F
InChi
InChI=1S/C32H30F2N4O4/c1-15-17 (7-6-10-24 (15)38-30 (40)19-8-5-9-21 (33)28 (19)37 (4)31 (38)41)25-22 (34)14-20 (29 (35)39)27-26 (25)18-12-11-16 (32 (2,3)42)13-23 (18)36-27/h5-10,14,16,36,42H,11-13H2,1-4H3, (H2,35,39)/t16-/m0/s1
InChi Key
ZRYMMWAJAFUANM-INIZCTEOSA-N

Product Categories/Family for BMS-986142 biochemical

Biochemicals; Enzyme Inhibitors; Enzyme Inhibitors (A-Z); Protein Kinase Inhibitors; Bruton's Tyrosine Kinase (BTK)Inhibitors; Biochemicals (A-Z)

Structure of BMS-986142 biochemical

BMS-986142 Biochemical – Cat# MBS848696

Product References and Citations for BMS-986142 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/86582336

Other Notes

Small volumes of BMS-986142 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMS-986142 purchase

MBS848696 is a biochemical targeting BMS-986142.
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