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HS-1371

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848706

HS-1371 is a potent RIP3 kinase inhibitor (IC50 = 20.8 nM). It binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro.. It inhibits TNF-induced necroptosis but does not inhibit TNF-induced apoptosis,… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
HS-1371, Biochemical
Full Product Name
HS-1371
Product Synonym Names
4- (4-methylphenoxy)-7- (1-piperidin-4-ylpyrazol-4-yl) quinoline; EX-A2073; HS1371
Form/Format
Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Molecular Weight
384.47
Solubility
>10 mg/ml DMSO
Molecular Formula
C??H??N??O
CAS Number
2158197-70-5
PubChem CID
134817449
SMILES
CC1=CC=C (C=C1)OC2=C3C=CC (=CC3=NC=C2)C4=CN (N=C4)C5CCNCC5
InChi
InChI=1S/C24H24N4O/c1-17-2-5-21 (6-3-17)29-24-10-13-26-23-14-18 (4-7-22 (23)24)19-15-27-28 (16-19)20-8-11-25-12-9-20/h2-7,10,13-16,20,25H,8-9,11-12H2,1H3
InChi Key
VPVLPCIBKVWFDT-UHFFFAOYSA-N

Product Categories/Family for HS-1371 biochemical

Biochemicals; Enzyme Inhibitors; Enzyme Inhibitors (A-Z); Biochemicals (A-Z); Protein Kinase Inhibitors; RIP Kinase Inhibitors

Structure of HS-1371 biochemical

Hs-1371 Biochemical – Cat# MBS848706

Product References and Citations for HS-1371 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/134817449#section=Top

Other Notes

Small volumes of HS-1371 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HS-1371 purchase

MBS848706 is a biochemical targeting HS-1371.
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