HDM-201 (Siremadlin)

Name: HDM-201 (Siremadlin); MyBioSource
Brand: MyBioSource
SKU: MBS848734
Price: 205 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848734

Siremadlin (NVP-HDM201) is a potent and highly specific MDM-2/p53 inhibitor. It binds to human MDM2 protein with a picomolar Ki value (0.21 nM). It activates p53 and induces robust p53-dependent cell cycle arrest and apoptosis in human p53 wild-type tumor… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

HDM-201, Biochemical

Full Product Name

HDM-201

Product Synonym Names

Siremadlin; NVP-HDM 201; (S)-5- (5-chloro-1-methyl-2-oxo-1; 2-dihydropyridin-3-yl)-6- (4-chlorophenyl)-2- (2; 4-dimethoxypyrimidin-5-yl)-1-isopropyl-5; 6-dihydropyrrolo[3; 4-d]imidazol-4 (1H)-one

Form/Format

Crystalline solid

Purity/Purification

>=98% by HPLC

Preparation and Storage

Store at -20 degree C
Shelf life: ~36 months

Molecular Weight

555.41

Solubility

>50 mg/ml in DMSO

Molecular Formula

C??H??Cl?N6O?

CAS Number

1448867-41-1

PubChem CID

71678098

SMILES

CC (C)N1C2=C (C (=O)N (C2C3=CC=C (C=C3)Cl)C4=CC (=CN (C4=O)C)Cl)N=C1C5=CN=C (N=C5OC)OC

InChi

InChI=1S/C26H24Cl2N6O4/c1-13 (2)33-21-19 (30-22 (33)17-11-29-26 (38-5)31-23 (17)37-4)25 (36)34 (18-10-16 (28)12-32 (3)24 (18)35)20 (21)14-6-8-15 (27)9-7-14/h6-13,20H,1-5H3/t20-/m0/s1

InChi Key

AGBSXNCBIWWLHD-FQEVSTJZSA-N

Product Categories/Family for HDM-201 biochemical

Enzyme Inhibitors; Enzyme Inhibitors (A-Z); Biochemicals; Biochemicals (A-Z); MDM2 Inhibitors

Product References and Citations for HDM-201 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/71678098

Other Notes

Small volumes of HDM-201 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HDM-201 purchase

MBS848734 is a biochemical targeting HDM-201.