Pf-04449913 (N-[ (2R)

Name: Pf-04449913 (N-[ (2R); MyBioSource
Brand: MyBioSource
SKU: MBS848742
Price: 205 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848742

PF-04449913 is a potent and orally bioavailable smoothened (SMO) inhibitor. PF-04449913 binds to human SMO with an IC50 of 4 nM. It has been shown to attenuate leukemia stem cell self-renewal and cell cycle progression in primary acute myeloid leukemia cells… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

PF-04449913, Biochemical

Full Product Name

PF-04449913

Product Synonym Names

N-[ (2R; 4R)-2- (1H-benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N'- (4-cyanophenyl)-urea

Form/Format

Crystalline solid

Purity/Purification

>=98% by HPLC

Preparation and Storage

Store at -20 degree C
Shelf life: ~36 months

Molecular Weight

374.4

Solubility

~20 mg/ml in DMSO

Molecular Formula

C??H??N?O

CAS Number

1095173-27-5

PubChem CID

25166913

SMILES

CN1CCC (CC1C2=NC3=CC=CC=C3N2)NC (=O)NC4=CC=C (C=C4)C#N

InChi

InChI=1S/C21H22N6O/c1-27-11-10-16 (24-21 (28)23-15-8-6-14 (13-22)7-9-15)12-19 (27)20-25-17-4-2-3-5-18 (17)26-20/h2-9,16,19H,10-12H2,1H3, (H,25,26)(H2,23,24,28)/t16-,19-/m1/s1

InChi Key

SFNSLLSYNZWZQG-VQIMIIECSA-N

Product Categories/Family for PF-04449913 biochemical

Enzyme Inhibitors; Enzyme Inhibitors (A-Z); Signaling Pathways; Hedgehog (Hh) Signaling Pathway; Antagonists; Biochemicals; Biochemicals (A-Z)

Product References and Citations for PF-04449913 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/25166913

Other Notes

Small volumes of PF-04449913 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PF-04449913 purchase

MBS848742 is a biochemical targeting PF-04449913.