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CHZ868

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848750

CHZ868 is a potent and selective type II JAK2 inhibitor (IC50 = 110 nM). JAK2 and MPL mutant cell lines are sensitive to CHZ868, including type I JAK inhibitor persistent cells. CHZ868 displays significant activity in murine MPN models and induces reductions… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CHZ868, Biochemical
Full Product Name
CHZ868
Product Synonym Names
CHZ-868; N- (4- ( (2- ( (2; 4-difluorophenyl) amino)-1; 4-dimethyl-1H-benzo[d]imidazol-5-yl) oxy) pyridin-2-yl) acetamide
Form/Format
Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Molecular Weight
423.42
Solubility
>100 mg/ml in DMSO
Molecular Formula
C??H??F?N?O?
CAS Number
1895895-38-1
PubChem CID
91885989
SMILES
CC1=C (C=CC2=C1N=C (N2C)NC3=C (C=C (C=C3)F)F)OC4=CC (=NC=C4)NC (=O)C
InChi
InChI=1S/C22H19F2N5O2/c1-12-19 (31-15-8-9-25-20 (11-15)26-13 (2)30)7-6-18-21 (12)28-22 (29 (18)3)27-17-5-4-14 (23)10-16 (17)24/h4-11H,1-3H3, (H,27,28)(H,25,26,30)
InChi Key
KQQLBXFPTDVFAJ-UHFFFAOYSA-N

Product Categories/Family for CHZ868 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; JAK Inhibitors; Protein Kinase Inhibitors (A-Z); Biochemicals; Biochemicals (A-Z); Enzyme Inhibitors (A-Z)

Structure of CHZ868 biochemical

CHZ868 Biochemical – Cat# MBS848750

Product References and Citations for CHZ868 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/91885989

Other Notes

Small volumes of CHZ868 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHZ868 purchase

MBS848750 is a biochemical targeting CHZ868.
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