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GNE-272

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848806

GNE-272 is a potent and selective in vivo probe for the bromodomains of CBP/EP300 (IC50 values of 0.02, 0.03 and 13 uM for CBP, EP300 and BRD4, respectively). Displays marked antiproliferative effect in hematologic cancer cell lines. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GNE-272, Biochemical
Full Product Name
GNE-272
Product Synonym Names
(S)-1- (3- ( (2-fluoro-4- (1-methyl-1H-pyrazol-4-yl) phenyl) amino)-1- (tetrahydrofuran-3-yl)-1; 4; 6; 7-tetrahydro-5H-pyrazolo[4; 3-c]pyridin-5-yl) ethan-1-one; GNE272
Form/Format
Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Molecular Weight
424.48
Solubility
>100 mg/ml in DMSO
Molecular Formula
C??H??FN?O?
CAS Number
1936428-93-1
PubChem CID
121372887
SMILES
CC (=O)N1CCC2=C (C1)C (=NN2C3CCOC3)NC4=C (C=C (C=C4)C5=CN (N=C5)C)F
InChi
InChI=1S/C22H25FN6O2/c1-14 (30)28-7-5-21-18 (12-28)22 (26-29 (21)17-6-8-31-13-17)25-20-4-3-15 (9-19 (20)23)16-10-24-27 (2)11-16/h3-4,9-11,17H,5-8,12-13H2,1-2H3, (H,25,26)/t17-/m0/s1
InChi Key
NKOJNOBJGYTLLZ-KRWDZBQOSA-N

Product Categories/Family for GNE-272 biochemical

Enzyme Inhibitors; Enzyme Inhibitors (A-Z); Biochemicals; Biochemicals (A-Z); Epigenetics; Epigenetic Modulators (A-Z); Epigenetics; Reader Domains; Bromodomains; Bromodomain Inhibitors

Structure of GNE-272 biochemical

GNE-272 Biochemical – Cat# MBS848806

Product References and Citations for GNE-272 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/121372887

Other Notes

Small volumes of GNE-272 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GNE-272 purchase

MBS848806 is a biochemical targeting GNE-272.
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