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BLU-667 (Pralsetinib)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848821

BLU-667 (Pralsetinib) is a highly potent and selective, next generation RET inhibitor with IC50 of 0.3-0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion. In vivo, BLU-667 potently inhibits growth of NSCLC and thyroid cancer xenografts… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
BLU-667 (Pralsetinib), Biochemical
Full Product Name
BLU-667 (Pralsetinib)
Product Synonym Names
Pralsetinib free base; cis-N-{ (1S)-1-[6- (4-fluoro-1H-pyrazol-1-yl) pyridin-3-yl]ethyl}-1-methoxy-4-{4-methyl-6-[ (5-methyl-1H-pyrazol-3-yl) amino]pyrimidin-2-yl}cyclohexane-1-carboxamide; BLU 667; BLU667
Form/Format
Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Molecular Weight
533.6
Solubility
>50 mg/ml in DMSO
Molecular Formula
C??H??FN?O?
CAS Number
2097132-94-8
PubChem CID
129073603
SMILES
CC1=CC (=NN1)NC2=NC (=NC (=C2)C)C3CCC (CC3)(C (=O)NC (C)C4=CN=C (C=C4)N5C=C (C=N5)F)OC
InChi
InChI=1S/C27H32FN9O2/c1-16-11-22 (33-23-12-17 (2)35-36-23)34-25 (31-16)19-7-9-27 (39-4,10-8-19)26 (38)32-18 (3)20-5-6-24 (29-13-20)37-15-21 (28)14-30-37/h5-6,11-15,18-19H,7-10H2,1-4H3, (H,32,38)(H2,31,33,34,35,36)/t18-,19,27/m0/s1
InChi Key
GBLBJPZSROAGMF-SIYOEGHHSA-N

Product Categories/Family for BLU-667 (Pralsetinib) biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Kinase Inhibitors  (A-Z); Biochemicals; Biochemicals (A-Z); Protein Tyrosine Kinase Inhibitors; Enzyme Inhibitors (A-Z)

Structure of BLU-667 (Pralsetinib) biochemical

BLU-667 (Pralsetinib) Biochemical – Cat# MBS848821

Product References and Citations for BLU-667 (Pralsetinib) biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/129073603

Other Notes

Small volumes of BLU-667 (Pralsetinib) biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BLU-667 (Pralsetinib) purchase

MBS848821 is a biochemical targeting BLU-667 (Pralsetinib).
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