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ML-385

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848876

ML-385 is a potent and selective Nrf2 inhibitor (Nrf2; IC50 = 1.9 uM). ML-385 blocks Nrf2 downstream target gene expression. ML-385 displays specificity and selectivity for NSCLC cells with KEAP1 mutation, which leads to gain of Nrf2 function. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
ML-385, Biochemical
Full Product Name
ML-385
Product Synonym Names
ML385; N-[4-[2; 3-Dihydro-1- (2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1; 3-benzodioxole-5-acetamide
Form/Format
White solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Molecular Weight
511.59
Solubility
>25 mg/ml in DMSO
Molecular Formula
C??H??N?O?S
CAS Number
846557-71-9
PubChem CID
1383822
SMILES
CC1=CC=CC=C1C (=O)N2CCC3=C2C=CC (=C3)C4=C (SC (=N4)NC (=O)CC5=CC6=C (C=C5)OCO6)C
InChi
InChI=1S/C29H25N3O4S/c1-17-5-3-4-6-22 (17)28 (34)32-12-11-20-15-21 (8-9-23 (20)32)27-18 (2)37-29 (31-27)30-26 (33)14-19-7-10-24-25 (13-19)36-16-35-24/h3-10,13,15H,11-12,14,16H2,1-2H3, (H,30,31,33)
InChi Key
LINHYWKZVCNAMQ-UHFFFAOYSA-N

Product Categories/Family for ML-385 biochemical

Biochemicals; Enzyme Inhibitors; Other Inhibitors; Enzyme Inhibitors (A-Z); Biochemicals (A-Z)

Structure of ML-385 biochemical

Ml-385 Biochemical – Cat# MBS848876

Product References and Citations for ML-385 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/1383822

Other Notes

Small volumes of ML-385 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ML-385 purchase

MBS848876 is a biochemical targeting ML-385.
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