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NMS-1286937

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848904

NMS-1286937 a potent, small-molecule Polo-like kinase 1 (PLK1) inhibitor (IC50 = 2 nM) with potential antineoplastic activity. It selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
NMS-1286937, Biochemical
Full Product Name
NMS-1286937
Product Synonym Names
NMS1286937; 1- (2-hydroxyethyl)-8-[5- (4-methylpiperazin-1-yl)-2- (trifluoromethoxy) anilino]-4; 5-dihydropyrazolo[4; 3-h]quinazoline-3-carboxamide
Form/Format
Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Molecular Weight
532.5
Solubility
>20 mg/ml in DMSO
Molecular Formula
C??H??F?N?O?
CAS Number
1034616-18-6
PubChem CID
49792852
SMILES
CN1CCN (CC1)C2=CC (=C (C=C2)OC (F)(F)F)NC3=NC=C4CCC5=C (C4=N3)N (N=C5C (=O)N)CCO
InChi
InChI=1S/C24H27F3N8O3/c1-33-6-8-34 (9-7-33)15-3-5-18 (38-24 (25,26)27)17 (12-15)30-23-29-13-14-2-4-16-20 (22 (28)37)32-35 (10-11-36)21 (16)19 (14)31-23/h3,5,12-13,36H,2,4,6-11H2,1H3, (H2,28,37)(H,29,30,31)
InChi Key
QHLVBNKYJGBCQJ-UHFFFAOYSA-N

Product Categories/Family for NMS-1286937 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Kinase Inhibitors  (A-Z); Biochemicals; Biochemicals (A-Z); Protein Tyrosine Kinase Inhibitors; Enzyme Inhibitors (A-Z)

Structure of NMS-1286937 biochemical

NMS-1286937 Biochemical – Cat# MBS848904

Product References and Citations for NMS-1286937 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/49792852

Other Notes

Small volumes of NMS-1286937 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NMS-1286937 purchase

MBS848904 is a biochemical targeting NMS-1286937.
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