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Brequinar Sodium

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848905

Brequinar sodium is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM). Blocks de novo pyrimidine biosynthesis. Displays minimal inhibition against a panel of >400 kinases. Triggers differentiation of AML cell lines. Causes… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Brequinar, Biochemical
Full Product Name
Brequinar Sodium
Product Synonym Names
NSC 368390; 6-Fluoro-2- (2'-fluoro[1; 1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium; Dup 785; BRQ
Form/Format
White solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Molecular Weight
397.35
Solubility
>35 mg/ml in DMSO
>35 mg/ml in Water
Molecular Formula
C??H??F?NO?Na
CAS Number
96201-88-6
PubChem CID
23663964
SMILES
CC1=C (C2=CC (F)=CC=C2N=C1C3=CC=C (C4=C (C=CC=C4)F)C=C3)C (O[Na])=O
InChi
InChI=1S/C23H15F2NO2.Na/c1-13-21 (23 (27)28)18-12-16 (24)10-11-20 (18)26-22 (13)15-8-6-14 (7-9-15)17-4-2-3-5-19 (17)25;/h2-12H,1H3, (H,27,28);/q;+1/p-1
InChi Key
PZOHOALJQOFNTB-UHFFFAOYSA-M

Product Categories/Family for Brequinar biochemical

Biochemicals; Enzyme Inhibitors; Other Inhibitors; Enzyme Inhibitors (A-Z); Biochemicals (A-Z)

Structure of Brequinar biochemical

Brequinar Sodium Biochemical – Cat# MBS848905

Product References and Citations for Brequinar biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/23663964

Other Notes

Small volumes of Brequinar biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Brequinar purchase

MBS848905 is a biochemical targeting Brequinar. Also known as Brequinar Sodium.
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