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TCS 21311

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS849022

TCS 21311 is a potent JAK3 (Janus kinase 3) inhibitor. It shows high selectivity for JAK3 over JAK1, JAK2 and TYK2 with IC50 values of 8 nM, 1017 nM, 2550 nM and 8055 nM respectively. It also inhibits GSK-3beta, PKCalpha and PKC? with IC50 values of 3 nM, 13… More details

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Product Documentation
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
TCS 21311, Biochemical
Full Product Name
TCS 21311
Product Synonym Names
3-[5-[4- (2-hydroxy-2-methylpropanoyl) piperazin-1-yl]-2- (trifluoromethyl) phenyl]-4- (1H-indol-3-yl) pyrrole-2; 5-dione; 3-[5-[4- (2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2- (trifluoromethyl) phenyl]-4- (1H-indol-3-yl)-1H-pyrrole-2; 5-dione; JAK3 Inhibitor XII; NIBR3049
Form/Format
Solid
Purity/Purification
0.95
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Molecular Weight
526.51
Solubility
~50 mg/ml in DMSO
Molecular Formula
C??H??F?N?O?
CAS Number
1260181-14-3
PubChem CID
50925411
SMILES
CC (C)(C (=O)N1CCN (CC1)C2=CC (=C (C=C2)C (F)(F)F)C3=C (C (=O)NC3=O)C4=CNC5=CC=CC=C54)O
InChi
InChI=1S/C27H25F3N4O4/c1-26 (2,38)25 (37)34-11-9-33 (10-12-34)15-7-8-19 (27 (28,29)30)17 (13-15)21-22 (24 (36)32-23 (21)35)18-14-31-20-6-4-3-5-16 (18)20/h3-8,13-14,31,38H,9-12H2,1-2H3, (H,32,35,36)
InChi Key
CLGRAWDGLMENOD-UHFFFAOYSA-N

Product Categories/Family for TCS 21311 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; JAK Inhibitors; Protein Kinase Inhibitors (A-Z); Biochemicals; Biochemicals (A-Z); Enzyme Inhibitors (A-Z)

Structure of TCS 21311 biochemical

TCS 21311 Biochemical – Cat# MBS849022

Product References and Citations for TCS 21311 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/50925411

Other Notes

Small volumes of TCS 21311 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TCS 21311 purchase

MBS849022 is a biochemical targeting TCS 21311.
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