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GNE-0877

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS849037

GNE-0877 is a selective, brain-penetrable Leucine-rich repeat kinase 2 (LRRK2) inhibitor with a Ki of 0.7 nM. Mutations in LRRK2 are associated with Parkinson's disease. GNE-0877 inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GNE-0877, Biochemical
Full Product Name
GNE-0877
Product Synonym Names
2-methyl-2-[3-methyl-4-[[4- (methylamino)-5- (trifluoromethyl) pyrimidin-2-yl]amino]pyrazol-1-yl]propanenitrile; alpha; alpha; 3-trimethyl-4-[[4- (methylamino)-5- (trifluoromethyl)-2-pyrimidinyl]amino]-1H-pyrazole-1-acetonitrile
Form/Format
A crystalline solid
Purity/Purification
0.9864
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Molecular Weight
339.32
Solubility
~15 mg/ml in DMSO
~1 mg/ml in ethanol
~10 mg/ml in DMF
Molecular Formula
C??H??F?N?
CAS Number
1374828-69-9
PubChem CID
69093374
SMILES
CC1=NN (C=C1NC2=NC=C (C (=N2)NC)C (F)(F)F)C (C)(C)C#N
InChi
InChI=1S/C14H16F3N7/c1-8-10 (6-24 (23-8)13 (2,3)7-18)21-12-20-5-9 (14 (15,16)17)11 (19-4)22-12/h5-6H,1-4H3, (H2,19,20,21,22)
InChi Key
ZPPUMAMZIMPJGP-UHFFFAOYSA-N

Product Categories/Family for GNE-0877 biochemical

Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Kinase Inhibitors  (A-Z); Biochemicals (A-Z); LRRK2 Inhibitors; Enzyme Inhibitors (A-Z); LRRK2 Inhibitors

Structure of GNE-0877 biochemical

GNE-0877 Biochemical – Cat# MBS849037

Product References and Citations for GNE-0877 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/69093374

Other Notes

Small volumes of GNE-0877 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GNE-0877 purchase

MBS849037 is a biochemical targeting GNE-0877.
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