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GNE-9605

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS849038

GNE-9605 is a selective, brain-penetrable Leucine-rich repeat kinase 2 (LRRK2) inhibitor with an IC50 of 19 nM. Mutations in LRRK2 are associated with Parkinson's disease. GNE-9065 inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GNE-9605, Biochemical
Full Product Name
GNE-9605
Product Synonym Names
2-N-[5-chloro-1-[ (3S; 4S)-3-fluoro-1- (oxetan-3-yl) piperidin-4-yl]pyrazol-4-yl]-4-N-methyl-5- (trifluoromethyl) pyrimidine-2; 4-diamine
Form/Format
A crystalline solid
Purity/Purification
0.9926
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Molecular Weight
449.83
Solubility
~20 mg/ml in DMSO
~1 mg/ml in methanol
Molecular Formula
C??H??ClF?N?O
CAS Number
1536200-31-3
PubChem CID
76328936
SMILES
CNC1=NC (=NC=C1C (F)(F)F)NC2=C (N (N=C2)C3CCN (CC3F)C4COC4)Cl
InChi
InChI=1S/C17H20ClF4N7O/c1-23-15-10 (17 (20,21)22)4-24-16 (27-15)26-12-5-25-29 (14 (12)18)13-2-3-28 (6-11 (13)19)9-7-30-8-9/h4-5,9,11,13H,2-3,6-8H2,1H3, (H2,23,24,26,27)/t11-,13-/m0/s1
InChi Key
PUXPEQJKNAWNQA-AAEUAGOBSA-N

Product Categories/Family for GNE-9605 biochemical

Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Kinase Inhibitors  (A-Z); Biochemicals (A-Z); LRRK2 Inhibitors; Enzyme Inhibitors (A-Z); LRRK2 Inhibitors

Structure of GNE-9605 biochemical

GNE-9605 Biochemical – Cat# MBS849038

Product References and Citations for GNE-9605 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/76328936

Other Notes

Small volumes of GNE-9605 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GNE-9605 purchase

MBS849038 is a biochemical targeting GNE-9605.
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