Flubendazole

Flubendazole is a benzimidazole carbamate anthelmintic agent. It eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection model when administered at doses of 5 and 50 mg/kg per day, respectively. It disrupts tubulin polymerization by showing preference for binding to nematode tubulin rather than the tubulin in host. Flubendazole inhibits mammalian tubulin polymerization with an IC50 of 2.5 uM. The microtubule-disrupting properties of benzimidazoles cause potential anti-cancer activity. The IC50 values for inhibition of proliferation of MDA-MB-231, BT-549, MCF-7 and SK-BR-3 cells are 1.75 uM, 0.72 uM, 5.51 uM and 1.51 uM, respectively.

https://pubchem.ncbi.nlm.nih.gov/compound/35802

Small volumes of Flubendazole biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS849050 is a biochemical targeting Flubendazole.