• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Glypican 3/GPC3 (GPC3) Human Cellexp Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS849804

Glypican-3 (GPC3) is also known as Intestinal protein OCI-5, GTR2-2, MXR7, which belongs to the glypican family. Glypican 3/GPC-3 is highly expressed in lung, liver and kidney. Glypican-3 inhibits the dipeptidyl peptidase activity of DPP4. Glypican-3 may be… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
Glypican 3/GPC3, Active Protein
Full Product Name
Human CellExp Glypican 3/GPC3, Mouse Recombinant
Product Gene Name
GPC3 active protein
Product Synonym Names
GPC3; OCI5; Glypican-3; GTR2-2; MXR7; DGSX; SDYS; SGB; SGBS; SGBS; SGBS1
Host
HEK293 cells
Form/Format
Lyophilized from 0.22 um filtered solution in PBS pH7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization.
Purity/Purification
>95% by SDS-PAGE
Preparation and Storage
Store at -20 degree C
Centrifuge the vial prior to opening.
Shelf life: ~12 months
Molecular Weight
65,332 Da
3D Structure
ModBase 3D Structure for Q8CFZ4
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Gene Source
Mouse
Endotoxin
<1.0 EU per/ug
Biological Activity
Immobilized Human FGF basic, Tag Free at 0.5 ug/mL (100 ul/well) can bind Mouse Glypican 3, His Tag with a linear range of 1-16 ng/ml.
Measured by its binding ability in a functional ELISA.
Reconstitution Instruction
Reconstitute in sterile deionized water to the desired protein concentration.

Product Categories/Family for GPC3 active protein

Proteins; Enzymes; Human cell expressed recombinant proteins; Proteins & Enzymes (A-Z)

SDS-Page of GPC3 active protein

Human Cellexp GPC3 Active Protein – Cat# MBS849804

Testing Data of GPC3 active protein

Human Cellexp GPC3 Active Protein, Testing Data – Cat# MBS849804

Testing Data of GPC3 active protein

Human Cellexp GPC3 Active Protein, Testing Data – Cat# MBS849804

Other Notes

Small volumes of GPC3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GPC3 purchase

MBS849804 is an active protein targeting GPC3. Also known as Human CellExp Glypican 3/GPC3, Mouse Recombinant. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for GPC3. It may not necessarily be applicable to this product.

NCBI GI #
31980680
NCBI GeneID
14734
NCBI Accession #
NP_057906.2
UniProt Primary Accession #
Q8CFZ4
UniProt Related Accession #
Q8CFZ4
GenBank Nucleotide #
NM_016697.3
NCBI Official Full Name
glypican-3
NCBI Official Synonym Full Names
glypican 3
NCBI Official Symbol
Gpc3
NCBI Official Synonym Symbols
OCI-5
UniProt Protein Name
Glypican-3
Protein Family
Glypican
UniProt Gene Name
Gpc3
NCBI Protein Information
glypican-3

UniProt Comments for GPC3

Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition ().
Show more

Research Articles on GPC3

1. This study provides new insights into the roles of GPC1 and GPC3 in mandibular morphogenesis. GPC3-knockout reduces mandibular growth, but GPC1 does not. These findings along with previous studies indicate that glypicans could be potential therapeutic agents to manage craniosynostosis and associated bony dysmorphology.
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GPC3 active protein

 Reference Product  PubMed Publications
 IGF2 active protein  >8 publications with GPC3 and IGF2
 FGF2 active protein  >5 publications with GPC3 and FGF2
 WNT3A active protein  >1 publications with GPC3 and WNT3A

Pathways associated with GPC3 active protein

 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 HS-GAG Biosynthesis Pathway antibodies  HS-GAG Biosynthesis Pathway Diagram
 HS-GAG Degradation Pathway antibodies  HS-GAG Degradation Pathway Diagram
 Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway antibodies  Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram

Diseases associated with GPC3 active protein

 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >249 publications with GPC3 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >215 publications with GPC3 and Liver Diseases
 Liver Neoplasms Antibodies  >212 publications with GPC3 and Liver Neoplasms
 Simpson-Golabi-Behmel syndrome Antibodies  >80 publications with GPC3 and Simpson-Golabi-Behmel syndrome
 Hepatitis Antibodies  >42 publications with GPC3 and Hepatitis
 Lung Neoplasms Antibodies  >27 publications with GPC3 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >25 publications with GPC3 and Neoplasm Metastasis
 Cardiovascular Diseases Antibodies  >24 publications with GPC3 and Cardiovascular Diseases
 Adenoma Antibodies  >21 publications with GPC3 and Adenoma
 Disease Models, Animal Antibodies  >21 publications with GPC3 and Disease Models, Animal

Organs/Tissues associated with GPC3 active protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >124 publications with GPC3 and Liver
 Blood Antibodies  >48 publications with GPC3 and Blood
 Kidney Antibodies  >22 publications with GPC3 and Kidney
 Bone Antibodies  >20 publications with GPC3 and Bone
 Embryonic Tissue Antibodies  >19 publications with GPC3 and Embryonic Tissue
 Lung Antibodies  >14 publications with GPC3 and Lung
 Heart Antibodies  >11 publications with GPC3 and Heart
 Ovary Antibodies  >9 publications with GPC3 and Ovary
 Vascular Antibodies  >8 publications with GPC3 and Vascular
 Placenta Antibodies  >7 publications with GPC3 and Placenta
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000