B3GNT6 Active Protein

Name: B3GNT6 Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS849848
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS849848

beta-1,3-N-acetylglucosaminyltransferase 6 (beta3GnT6) transfers N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to N-acetylgalactosamine (GalNAc). beta3GnT6 is also known as the core 3 synthase, because it creates the core 3 oligosaccharide structure in the… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

B3GNT6, Active Protein

Full Product Name

B3GNT6, soluble fragment, Human Recombinant

Product Gene Name

B3GNT6 active protein

Product Synonym Names

Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1; 3-N acetylglucosaminyltransferase; Core 3 synthase; UDP-GlcNAc:betaGal beta-1; 3-N-acetylglucosaminyltransferase 6; BGnT-6; Beta-1; 3-Gn-T6

Host

Insect cells

Form/Format

Liquid. Sterile filtered solution in 25mM Tris pH7.5 and 150mM NaCl

Purity/Purification

>95% by SDS-PAGE

Concentration

100ug/ml (lot specific)

Preparation and Storage

Store at -20 degree C
Centrifuge the vial prior to opening.
Shelf life: ~12 months

Molecular Weight

42,748 Da

Chromosome Location

Chromosome: 11; NC_000011.9 (76745385..76753020). Location: 11q13.4

OMIM

615315

3D Structure

ModBase 3D Structure for Q6ZMB0

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Gene Source

Human

Biological Activity

Specific activity >100 pmol/min/ug
Measured by transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to 4-Nitrophenyl-N-acetylgalactosamine, as measured with a phosphatase-coupled assay.

Product Categories/Family for B3GNT6 active protein

Proteins; Enzymes; Proteins & Enzymes (A-Z); Glycosyltransferase Enzymes

Other Notes

Small volumes of B3GNT6 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for B3GNT6 purchase

MBS849848 is an active protein targeting B3GNT6. Also known as B3GNT6, soluble fragment, Human Recombinant. Host: Insect cells.

Additional Details

NCBI/Uniprot data below describe general gene information for B3GNT6. It may not necessarily be applicable to this product.

NCBI GI #

19263732

NCBI GeneID

192134

NCBI Accession #

AAH25357.1

UniProt Primary Accession #

Q6ZMB0

UniProt Secondary Accession #

Q6ZSC5; Q8TAZ4; Q8TDX1; E9PKS1

UniProt Related Accession #

Q6ZMB0

NCBI Official Full Name

B3GNT6 protein

NCBI Official Synonym Full Names

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)

NCBI Official Symbol

B3GNT6

NCBI Official Synonym Symbols

BGnT-6; B3Gn-T6; beta3Gn-T6; beta-1,3-Gn-T6

UniProt Protein Name

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6

UniProt Synonym Protein Names

Core 3 synthase

Protein Family

Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase

UniProt Gene Name

B3GNT6

UniProt Synonym Gene Names

BGnT-6; Beta-1,3-Gn-T6; Beta-1,3-N-acetylglucosaminyltransferase 6; Beta3Gn-T6

UniProt Entry Name

B3GN6_HUMAN

NCBI Protein Information

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6; core 3 synthase; beta-1,3-N-acetylglucosaminyltransferase protein

UniProt Comments for B3GNT6

B3GNT6: Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs. Belongs to the glycosyltransferase 31 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; Membrane protein, integral; Glycan Metabolism - O-glycan biosynthesis; EC 2.4.1.-

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: Golgi membrane; membrane; integral to membrane

Molecular Function: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity; galactosyltransferase activity

Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; glycoprotein biosynthetic process; O-glycan processing; O-glycan processing, core 3; post-translational protein modification

Research Articles on B3GNT6

1. alpha2beta1 integrin acquired core3 O-glycans in cells expressing core3 synthase with decreased maturation of beta1 integrin, leading to decreased levels of the alpha2beta1 integrin complex

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with B3GNT6 active protein

Products by Pathway	Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Mucin Type O-Glycan Biosynthesis Pathway antibodies	Mucin Type O-Glycan Biosynthesis Pathway Diagram
Mucin Type O-Glycan Biosynthesis Pathway antibodies	Mucin Type O-Glycan Biosynthesis Pathway Diagram
O-glycan Biosynthesis, Mucin Type Core Pathway antibodies	O-glycan Biosynthesis, Mucin Type Core Pathway Diagram
O-glycan Biosynthesis, Mucin Type Core Pathway antibodies	O-glycan Biosynthesis, Mucin Type Core Pathway Diagram
O-linked Glycosylation Of Mucins Pathway antibodies	O-linked Glycosylation Of Mucins Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram

Diseases associated with B3GNT6 active protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1 publications with B3GNT6 and Neoplasms