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CD48/SLAMF2 (CD48) Human Cellexp Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS849870

CD48 antigen is also known as Signaling lymphocytic activation molecule 2, SLAM family member 2 (SLAMF2), Leukocyte antigen MEM-102, BCM1 surface antigen, B-lymphocyte activation marker BLAST-1. CD48 is a 65 kDa GPI-linked protein which belongs to the CD2… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CD48/SLAMF2, Active Protein
Full Product Name
Human CellExp CD48/SLAMF2, Fc Tag, Human Recombinant
Product Gene Name
CD48 active protein
Product Synonym Names
CD48; BCM1; SLAMF2; BLAST1; BLAST; BLAST1; MEM-102; TCT.1; BCM-1; SLAMF-2; BLAST-1
Host
HEK293 cells
Form/Format
Lyophilized from 0.22 um filtered solution in 50mM Tris, 100mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.
Purity/Purification
>=95% by SDS-PAGE
Preparation and Storage
Store at -20 degree C
Centrifuge the vial prior to opening.
Shelf life: ~12 months
Molecular Weight
19,429 Da
OMIM
M59904 mRNA
3D Structure
ModBase 3D Structure for P09326
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Gene Source
Human
Endotoxin
<1 EU/ug by LAL method
Biological Activity
Immobilized Human 2B4, His Tag at 2 ug/mL (100 uL/well) can bind Human CD48, Fc Tag with a linear range of 0.078-2.5 ug/ml.
Measured by its binding ability in a functional ELISA.
Reconstitution Instruction
Reconstitute in sterile deionized water to a concentration of 50 ug/ml.

Product Categories/Family for CD48 active protein

Proteins; Enzymes; Human cell expressed recombinant proteins; Cytokines; Growth Factors & Hormones; CDs; Cytokines; Cytokines & Growth Factors (A-Z); Proteins & Enzymes (A-Z)

SDS-Page of CD48 active protein

Human Cellexp CD48 Active Protein – Cat# MBS849870

Testing Data of CD48 active protein

Human Cellexp CD48 Active Protein, Testing Data – Cat# MBS849870

Other Notes

Small volumes of CD48 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD48 purchase

MBS849870 is an active protein targeting CD48. Also known as Human CellExp CD48/SLAMF2, Fc Tag, Human Recombinant. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CD48. It may not necessarily be applicable to this product.

NCBI GI #
114871
NCBI GeneID
962
NCBI Accession #
P09326.2
UniProt Primary Accession #
P09326
UniProt Secondary Accession #
Q5U055; Q8MGR0
UniProt Related Accession #
P09326
NCBI Official Full Name
CD48 antigen
NCBI Official Synonym Full Names
CD48 molecule
NCBI Official Symbol
CD48
NCBI Official Synonym Symbols
BCM1; BLAST; hCD48; mCD48; BLAST1; SLAMF2; MEM-102
UniProt Protein Name
CD48 antigen
UniProt Synonym Protein Names
B-lymphocyte activation marker BLAST-1; BCM1 surface antigen; Leukocyte antigen MEM-102; SLAM family member 2; SLAMF2; Signaling lymphocytic activation molecule 2; TCT.1; CD_antigen: CD48
Protein Family
CD48 antigen
UniProt Gene Name
CD48
UniProt Synonym Gene Names
BCM1; BLAST1; SLAMF2
NCBI Protein Information
CD48 antigen

NCBI Summary for CD48

This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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UniProt Comments for CD48

Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.

Research Articles on CD48

1. The present study provides further insights into the role of the 2B4-CD48 interaction in the fine regulation of CD8(+) T-cell effector function upon antigenic stimulation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD48 active protein

 Reference Product  PubMed Publications
 CD244 active protein  >102 publications with CD48 and CD244
 PTPRC active protein  >19 publications with CD48 and PTPRC
 LCK active protein  >15 publications with CD48 and LCK
 CD52 active protein  >7 publications with CD48 and CD52
 FYN active protein  >6 publications with CD48 and FYN
 CD53 active protein  >5 publications with CD48 and CD53
 IL18 active protein  >4 publications with CD48 and IL18

Pathways associated with CD48 active protein

 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Gastric Cancer Network 2 Pathway antibodies  Gastric Cancer Network 2 Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram

Diseases associated with CD48 active protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >26 publications with CD48 and Necrosis
 Disease Models, Animal Antibodies  >19 publications with CD48 and Disease Models, Animal
 Inflammation Antibodies  >16 publications with CD48 and Inflammation
 Neoplasms, Experimental Antibodies  >15 publications with CD48 and Neoplasms, Experimental
 Skin Diseases Antibodies  >9 publications with CD48 and Skin Diseases
 Carcinoma Antibodies  >7 publications with CD48 and Carcinoma
 Cardiovascular Diseases Antibodies  >6 publications with CD48 and Cardiovascular Diseases
 Liver Diseases Antibodies  >5 publications with CD48 and Liver Diseases
 Brain Diseases Antibodies  >5 publications with CD48 and Brain Diseases
 Congenital Abnormalities Antibodies  >4 publications with CD48 and Congenital Abnormalities

Organs/Tissues associated with CD48 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >317 publications with CD48 and Blood
 Bone Marrow Antibodies  >67 publications with CD48 and Bone Marrow
 Spleen Antibodies  >23 publications with CD48 and Spleen
 Lung Antibodies  >12 publications with CD48 and Lung
 Brain Antibodies  >11 publications with CD48 and Brain
 Vascular Antibodies  >9 publications with CD48 and Vascular
 Skin Antibodies  >9 publications with CD48 and Skin
 Thymus Antibodies  >9 publications with CD48 and Thymus
 Placenta Antibodies  >7 publications with CD48 and Placenta
 Lymph Node Antibodies  >7 publications with CD48 and Lymph Node
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