Human Cellexp NECTIN2 Active Protein – Cat# MBS849994

Nectin-2/CD112 (NECTIN2) Human Cellexp Active Protein

Name: NECTIN2 Active Protein; Nectin-2/CD112; Human Cellexp; MyBioSource
Brand: MyBioSource
SKU: MBS849994
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS849994

Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Nectin-2/CD112 (NECTIN2), Active Protein

Full Product Name

Human CellExp Nectin-2/CD112, Human Recombinant

Product Gene Name

NECTIN2 active protein

Product Synonym Names

CD112; Nectin-2; PVRL2

Host

HEK293 cells

Form/Format

Lyophilized from 0.22 um filtered solution in PBS, pH5.0. Normally trehalose is added as protectant before lyophilization.

Purity/Purification

>=95% by SDS-PAGE

Preparation and Storage

Store at -20 degree C
Centrifuge the vial prior to opening.
Shelf life: ~12 months

Molecular Weight

51,359 Da

OMIM

X80038 mRNA

3D Structure

ModBase 3D Structure for Q92692

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Gene Source

Human

Endotoxin

<1.0 EU per 1 ug of protein

Biological Activity

Immobilized Human PVRIG, Mouse IgG2a Fc Tag, low endotoxin at 2 ug/mL (100 uL/well) can bind Human Nectin-2, His Tag with a linear range of 0.078-0.625 ug/mL
Measured by its binding ability in a functional ELISA

Reconstitution Instruction

Reconstitute in sterile deionized water to a concentration of 100 ug/ml.

Product Categories/Family for NECTIN2 active protein

Proteins; Enzymes; Human cell expressed recombinant proteins; Cytokines; Growth Factors & Hormones; CDs; Cytokines; Cytokines & Growth Factors (A-Z); Proteins & Enzymes (A-Z)

Other Notes

Small volumes of NECTIN2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NECTIN2 purchase

MBS849994 is an active protein targeting NECTIN2. Also known as Human CellExp Nectin-2/CD112, Human Recombinant. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for NECTIN2. It may not necessarily be applicable to this product.

NCBI GI #

12643789

NCBI GeneID

5819

NCBI Accession #

Q92692.1

UniProt Primary Accession #

Q92692

UniProt Secondary Accession #

O75455; Q6IBI6; Q96J29; A8K5L5

UniProt Related Accession #

Q92692

NCBI Official Full Name

Nectin-2

NCBI Official Synonym Full Names

nectin cell adhesion molecule 2

NCBI Official Symbol

NECTIN2

NCBI Official Synonym Symbols

HVEB; PRR2; CD112; PVRL2; PVRR2

UniProt Protein Name

Nectin-2

UniProt Synonym Protein Names

Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Nectin cell adhesion molecule 2

Protein Family

Nectin

UniProt Gene Name

NECTIN2

UniProt Synonym Gene Names

Herpesvirus entry mediator B; HveB

NCBI Protein Information

nectin-2

NCBI Summary for NECTIN2

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

UniProt Comments for NECTIN2

Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).

Research Articles on NECTIN2

1. In the infection with 3 MLD50 (50 % mouse lethal dose), effective resistance was not observed in transgenic mice expressing nectin-2Ig.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NECTIN2 active protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Adherens Junction Pathway antibodies	Adherens Junction Pathway Diagram
Adherens Junction Pathway antibodies	Adherens Junction Pathway Diagram
Adherens Junctions Interactions Pathway antibodies	Adherens Junctions Interactions Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Junction Organization Pathway antibodies	Cell Junction Organization Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
Cell-cell Junction Organization Pathway antibodies	Cell-cell Junction Organization Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram

Diseases associated with NECTIN2 active protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>1 publications with NECTIN2 and Necrosis

Organs/Tissues associated with NECTIN2 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1 publications with NECTIN2 and Blood
Embryonic Tissue Antibodies	>1 publications with NECTIN2 and Embryonic Tissue
Placenta Antibodies	>1 publications with NECTIN2 and Placenta
Testis Antibodies	>1 publications with NECTIN2 and Testis