Human Cellexp TNFSF13 Active Protein – Cat# MBS849995

APRIL/TNFSF13 (TNFSF13) Human Cellexp Active Protein

Name: TNFSF13 Active Protein; APRIL/TNFSF13; Human Cellexp; MyBioSource
Brand: MyBioSource
SKU: MBS849995
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS849995

APRIL (a proliferation-inducing ligand) is also known as Tumor necrosis factor ligand superfamily member 13, TALL-2, TRDL-1, CD256, TNFFSF 13, cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. APRIL is a cytokine of the tumor necrosis factor family… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

APRIL/TNFSF13, Active Protein

Full Product Name

Human CellExp APRIL/TNFSF13, Human Recombinant

Product Gene Name

TNFSF13 active protein

Product Synonym Names

APRIL; TNFSF13; TALL-2; TRDL-1; CD256; TALL2; ZTNF2

Host

HEK293 cells

Form/Format

Lyophilized from 0.22 um filtered solution in 50mM Tris, 100mM Glycine, 25mM Arginine, 150mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Purity/Purification

>=95% by SDS-PAGE

Preparation and Storage

Store at -20 degree C
Centrifuge the vial prior to opening.
Shelf life: ~12 months

Molecular Weight

27,433 Da

Chromosome Location

Chromosome: 17; NC_000017.10 (7461609..7464925). Location: 17p13.1

OMIM

604472

3D Structure

ModBase 3D Structure for O75888

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Gene Source

Human

Endotoxin

<1.0 EU per 1 ug of protein

Biological Activity

Immobilized Human BCMA, Mouse IgG2a Fc Tag at 5 ug/mL (100 uL/well) can bind Human APRIL, Fc Tag with a linear range of 0.6-10 ng/mL
Measured by its binding ability in a functional ELISA

Reconstitution Instruction

Reconstitute in sterile deionized water to a concentration of 100 ug/ml.

Product Categories/Family for TNFSF13 active protein

Cytokines; Growth Factors & Hormones; TNFs; Enzymes; TNFs; Proteins; Enzymes; Cytokines & Growth Factors (A-Z); Proteins & Enzymes (A-Z); Signaling Pathways; NF kappaB Signaling; Animal Free Origin (AOF); Recombinant Proteins & Enzymes

Other Notes

Small volumes of TNFSF13 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFSF13 purchase

MBS849995 is an active protein targeting TNFSF13. Also known as Human CellExp APRIL/TNFSF13, Human Recombinant. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFSF13. It may not necessarily be applicable to this product.

NCBI GI #

310750387

NCBI GeneID

8741

NCBI Accession #

NP_001185552.1

UniProt Primary Accession #

O75888

UniProt Secondary Accession #

Q541E1; Q5U0G8; Q96HV6; Q9P1M8; Q9P1M9; B4DVT2

UniProt Related Accession #

O75888

GenBank Nucleotide #

NM_001198623.1

NCBI Official Full Name

tumor necrosis factor ligand superfamily member 13 isoform zeta

NCBI Official Synonym Full Names

tumor necrosis factor (ligand) superfamily, member 13

NCBI Official Symbol

TNFSF13

NCBI Official Synonym Symbols

APRIL; CD256; TALL2; ZTNF2; TALL-2; TRDL-1; UNQ383/PRO715

UniProt Protein Name

Tumor necrosis factor ligand superfamily member 13

UniProt Synonym Protein Names

A proliferation-inducing ligand; APRIL; TNF- and APOL-related leukocyte expressed ligand 2; TALL-2; TNF-related death ligand 1

Protein Family

Tumor necrosis factor ligand superfamily

UniProt Gene Name

TNFSF13

UniProt Synonym Gene Names

APRIL; TALL2; ZTNF2; APRIL; TALL-2; TRDL-1

UniProt Entry Name

TNF13_HUMAN

NCBI Protein Information

tumor necrosis factor ligand superfamily member 13; a proliferation-inducing ligand; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1; TNF- and APOL-related leukocyte expressed ligand 2

NCBI Summary for TNFSF13

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

UniProt Comments for TNFSF13

TNFSF13: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Belongs to the tumor necrosis factor family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: nucleoplasm; extracellular space; cytoplasm; cytosol; external side of plasma membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: immunoglobulin production in mucosal tissue; positive regulation of cell proliferation; positive regulation of germinal center formation; gene expression; signal transduction; positive regulation of isotype switching to IgA isotypes

Research Articles on TNFSF13

1. Serum APRIL levels inversely correlate with serum IgG4 levels in patients with IgG4-related disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TNFSF13 active protein

Reference Product	PubMed Publications
TNFSF13B active protein	>89 publications with TNFSF13 and TNFSF13B
TNFRSF17 active protein	>55 publications with TNFSF13 and TNFRSF17
TNFRSF13B active protein	>43 publications with TNFSF13 and TNFRSF13B
FURIN active protein	>5 publications with TNFSF13 and FURIN
TNFRSF11B active protein	>2 publications with TNFSF13 and TNFRSF11B
FAS active protein	>2 publications with TNFSF13 and FAS

Pathways associated with TNFSF13 active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram
Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway antibodies	Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway Diagram
Rheumatoid Arthritis Pathway antibodies	Rheumatoid Arthritis Pathway Diagram
Rheumatoid Arthritis Pathway antibodies	Rheumatoid Arthritis Pathway Diagram
Spinal Cord Injury Pathway antibodies	Spinal Cord Injury Pathway Diagram
Stabilization Of MRNA By HuR Pathway antibodies	Stabilization Of MRNA By HuR Pathway Diagram

Diseases associated with TNFSF13 active protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>191 publications with TNFSF13 and Necrosis
Neoplasms Antibodies	>64 publications with TNFSF13 and Neoplasms
Inflammation Antibodies	>20 publications with TNFSF13 and Inflammation
Disease Models, Animal Antibodies	>12 publications with TNFSF13 and Disease Models, Animal
Cardiovascular Diseases Antibodies	>11 publications with TNFSF13 and Cardiovascular Diseases
Multiple Myeloma Antibodies	>10 publications with TNFSF13 and Multiple Myeloma
Nervous System Diseases Antibodies	>7 publications with TNFSF13 and Nervous System Diseases
Colorectal Neoplasms Antibodies	>6 publications with TNFSF13 and Colorectal Neoplasms
Neoplasms, Experimental Antibodies	>5 publications with TNFSF13 and Neoplasms, Experimental
Kidney Diseases Antibodies	>4 publications with TNFSF13 and Kidney Diseases

Organs/Tissues associated with TNFSF13 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>148 publications with TNFSF13 and Blood
Bone Antibodies	>17 publications with TNFSF13 and Bone
Spleen Antibodies	>15 publications with TNFSF13 and Spleen
Lung Antibodies	>9 publications with TNFSF13 and Lung
Kidney Antibodies	>8 publications with TNFSF13 and Kidney
Lymph Node Antibodies	>8 publications with TNFSF13 and Lymph Node
Skin Antibodies	>6 publications with TNFSF13 and Skin
Vascular Antibodies	>5 publications with TNFSF13 and Vascular
Liver Antibodies	>4 publications with TNFSF13 and Liver
Thymus Antibodies	>3 publications with TNFSF13 and Thymus